Evidence map›Paper›PMID 21249428›Full record

ArticleMolecular and cellular biochemistry2011

Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes.

M Balasubramanyam, S Aravind, K Gokulakrishnan, P Prabu, C Sathishkumar, H Ranjani, V Mohan

Abstract read
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Article in Molecular and cellular biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 4 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 4 syntheses or guidelines pooled it, 233 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus.International journal of molecular sciences · 2017
    Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Genomic and Transcriptomic Variations ofJournal of nutrition and metabolism · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Observational
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. MiRNA-146a-A Key Player in Immunity and Diseases.International journal of molecular sciences · 2023
    Review
  19. Article
  20. Article

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

M BalasubramanyamDepartment of Cell and Molecular Biology, Madras Diabetes Research Foundation, Gopalapuram, Chennai 600086, India. balusignal@gmail.com
S Aravind
K Gokulakrishnan
P Prabu
C Sathishkumar
H Ranjani
V Mohan
Madras Diabetes Research Foundation · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes patients exhibit subclinical inflammation but the regulatory mechanisms are poorly understood. We sought to evaluate the role of miR-146a expression along with its downstream proinflammatory signals in relation to glycemic control and insulin resistance. Study subjects (n = 20 each) comprised of clinically well characterized Type 2 diabetes patients and control non-diabetic subjects. miRNA and mRNA expression levels were probed in peripheral blood mononuclear cells (PBMC) by Real-time RT-PCR and plasma levels of TNFα and IL-6 were measured by ELISA. The miR-146a expression levels were significantly decreased in PBMCs from patients with Type 2 diabetes compared to control subjects. Among the target genes of miR-146a, TRAF-6 mRNA expression was significantly increased in patients with Type 2 diabetes while there was no significant difference in the mRNA levels of IRAK1 in the study groups. In contrast, there were significantly increased levels of NFκB expression in patients with Type 2 diabetes. There was an increased trend in the levels of TNFα and IL-6 mRNA in patients with type 2 diabetes. While SOCS-3 mRNA levels increased, plasma TNFα and IL-6 levels were also significantly higher in patients with type 2 diabetes. miR-146a expression was negatively correlated to glycated hemoglobin, insulin resistance, TRAF6, and NFκB mRNA levels and circulatory levels of TNFα and IL-6. Reduced miR-146a levels are associated with insulin resistance, poor glycemic control, and several proinflammatory cytokine genes and circulatory levels of TNFα and IL-6 in Asian Indian Type 2 diabetic patients.

Indexed as

Insulin ResistanceAdultBlood GlucoseCase-Control StudiesDiabetes Mellitus, Type 2Enzyme-Linked Immunosorbent AssayHumansInflammationInterleukin-6MicroRNAsMiddle AgedReverse Transcriptase Polymerase Chain ReactionTumor Necrosis Factor-alphaBlood GlucoseInterleukin-6MicroRNAsMIRN146 microRNA, humanTumor Necrosis Factor-alpha

Identifiers

PMID21249428
OpenAlexW2104776720

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.