Trial reportEuropean journal of applied physiology2011
Changes in salivary antimicrobial peptides, immunoglobulin A and cortisol after prolonged strenuous exercise.
Trial report in European journal of applied physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Impact of exercise on markers of B cell-related immunity: A systematic review.Journal of sport and health science · 2024Pooled it
- Effects of different exercise intensities or durations on salivary IgA secretion.European journal of applied physiology · 2024Trial
- Trial
- Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise.Journal of dietary supplements · 2013Trial
- Competitive Stress Elicits Distinct Psychophysiological and Immunological Responses in Sub-Elite Water Polo Players.Sports (Basel, Switzerland) · 2026Article
- Circulating Antimicrobial Peptides as Biomarkers of Inflammation and Airway Dysfunction After Marathon Running.Biology · 2025Article
- The Variability of the Salivary Antimicrobial Peptide Profile: Impact of Lifestyle.International journal of molecular sciences · 2024Review
- Effects of Diabetes and Voluntary Exercise on IgA Concentration and Polymeric Immunoglobulin Receptor Expression in the Submandibular Gland of Rats.Medicina (Kaunas, Lithuania) · 2023Article
- Beyond the Finish Line: The Impact and Dynamics of Biomarkers in Physical Exercise-A Narrative Review.Journal of clinical medicine · 2021Review
- Effect of Tourist Activities on Fecal and Salivary Glucocorticoids and Immunoglobulin A in Female Captive Asian Elephants in Thailand.Animals : an open access journal from MDPI · 2020Article
- HNP-1 and HBD-1 as Biomarkers for the Immune Systems of Elite Basketball Athletes.Antibiotics (Basel, Switzerland) · 2020Article
- Effects of Carbohydrate Mouth Rinsing on Salivary Lysozyme, Mood States and Running Performance Among Recreational Runners.The Malaysian journal of medical sciences : MJMS · 2020Article
- Salivary extracellular heat shock protein 70 (eHSP70) levels increase after 59 min of intense exercise and correlate with resting salivary secretory immunoglobulin A (SIgA) levels at rest.Cell stress & chaperones · 2016Article
- Fitness level impacts salivary antimicrobial protein responses to a single bout of cycling exercise.European journal of applied physiology · 2015Article
- A single bout of resistance exercise can enhance episodic memory performance.Acta psychologica · 2014Article
- Effects of aerobic exercise on lipid-effector molecules of the innate immune response.Medicine and science in sports and exercise · 2014Article
- Salivary concentration of the antimicrobial peptide LL-37 in patients with oral lichen planus.Journal of oral microbiology · 2014Article
- Effects of yoga exercise on salivary beta-defensin 2.European journal of applied physiology · 2013Article
- Effects of High-Intensity Endurance Exercise on Epidermal Barriers against Microbial Invasion.Journal of sports science & medicine · 2013Article
- Stress and the HPA axis: role of glucocorticoids in alcohol dependence.Alcohol research : current reviews · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to examine whether amount of oral antimicrobial components, human β-defensin-2 (HBD-2), cathelicidin (LL-37), and immunoglobulin A (IgA), might be affected by prolonged strenuous exercise. Ten young male volunteers either exercised on recumbent ergometer at 75% [Formula: see text] for 60 min (exercise session) or sat quietly (resting session). Saliva samples were obtained at 60-min intervals during sessions for measurements of saliva antimicrobial components (HBD-2, LL-37, and IgA), saliva cortisol and osmolality. Saliva flow rate was decreased and saliva osmolality was increased during the 60-min exercise. Saliva HBD-2 and LL-37 concentrations and secretion rates were increased during and after the exercise, whereas saliva IgA concentration and secretion rates were decreased after the exercise. Saliva cortisol was increased during and after the exercise. The areas under the curve of the time courses of saliva levels of HBD-2 and LL-37 were negatively correlated with those of cortisol levels in saliva. The present findings suggested that a single bout of prolonged strenuous exercise caused a transient increase in the oral HBD-2 and LL-37 levels.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.