ArticlePloS one2011
Intrinsic regulation of spatiotemporal organization within the suprachiasmatic nucleus.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- Interpretable machine learning reveals hemispheric asymmetry of state switching in the suprachiasmatic nucleus.Patterns (New York, N.Y.) · 2026Article
- CaMKIIα mediates feedback effects of wheel-running activity on the circadian pacemaker in mice.Scientific reports · 2026Article
- Circadian Behavioral and Bioluminescence Rhythms in theJournal of biological rhythms · 2026Article
- Reconsidering mammalian circadian organization.Neurobiology of sleep and circadian rhythms · 2026Article
- Toward dissection of diverse neural components in the suprachiasmatic nucleus (SCN) pacemaker network.Neurobiology of sleep and circadian rhythms · 2026Article
- Behavioral and brain-wide neural signatures of sundowning in Alzheimer's disease.Research square · 2026Article
- Time after time - circadian clocks through the lens of oscillator theory.FEBS letters · 2026Review
- The inferred functional connectome underlying circadian synchronization in the mouse suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Suprachiasmatic nucleus-wide estimation of oscillatory temporal dynamics.PLoS computational biology · 2025Article
- The Functional Connectome Mediating Circadian Synchrony in the Suprachiasmatic Nucleus.bioRxiv : the preprint server for biology · 2024Article
- On the origin and evolution of the dual oscillator model underlying the photoperiodic clockwork in the suprachiasmatic nucleus.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- System-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning.Cell research · 2024Article
- The seasons within: a theoretical perspective on photoperiodic entrainment and encoding.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward.Journal of biological rhythms · 2024Review
- Daily rhythm in cortical chloride homeostasis underpins functional changes in visual cortex excitability.Nature communications · 2023Article
- A Journey in the Brain's Clock: In Vivo Veritas?Biology · 2023Review
- Arginine-vasopressin-expressing neurons in the murine suprachiasmatic nucleus exhibit a circadian rhythm in network coherence in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Developmental patterning of peptide transcription in the central circadian clock in both sexes.Frontiers in neuroscience · 2023Article
- Tempo: an unsupervised Bayesian algorithm for circadian phase inference in single-cell transcriptomics.Nature communications · 2022Article
- Deciphering clock cell network morphology within the biological master clock, suprachiasmatic nucleus: From the perspective of circadian wave dynamics.PLoS computational biology · 2022Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
The mammalian pacemaker in the suprachiasmatic nucleus (SCN) contains a population of neural oscillators capable of sustaining cell-autonomous rhythms in gene expression and electrical firing. A critical question for understanding pacemaker function is how SCN oscillators are organized into a coherent tissue capable of coordinating circadian rhythms in behavior and physiology. Here we undertake a comprehensive analysis of oscillatory function across the SCN of the adult PER2::LUC mouse by developing a novel approach involving multi-position bioluminescence imaging and unbiased computational analyses. We demonstrate that there is phase heterogeneity across all three dimensions of the SCN that is intrinsically regulated and extrinsically modulated by light in a region-specific manner. By investigating the mechanistic bases of SCN phase heterogeneity, we show for the first time that phase differences are not systematically related to regional differences in period, waveform, amplitude, or brightness. Furthermore, phase differences are not related to regional differences in the expression of arginine vasopressin and vasoactive intestinal polypeptide, two key neuropeptides characterizing functionally distinct subdivisions of the SCN. The consistency of SCN spatiotemporal organization across individuals and across planes of section suggests that the precise phasing of oscillators is a robust feature of the pacemaker important for its function.
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Registered trials
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