ArticlePloS one2011
Unusual regulation of a leaderless operon involved in the catabolism of dimethylsulfoniopropionate in Rhodobacter sphaeroides.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Metabolic Regulation of Dimethylsulfoniopropionate Cleavage and Dimethyl Sulfide Production in Halomonas sp. D47.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- EefR mutations drive sanguinarine resistance by activating cryptic multidrug efflux pumps in AcrB-NullVirulence · 2025Article
- Cloning and expression of the dimethylsulfoniopropionate lyase geneCurrent research in microbial sciences · 2025Article
- TFBMiner: A User-Friendly Command Line Tool for the Rapid Mining of Transcription Factor-Based Biosensors.ACS synthetic biology · 2023Article
- Biogeographic traits of dimethyl sulfide and dimethylsulfoniopropionate cycling in polar oceans.Microbiome · 2021Article
- Construction of a switchable synthetic Escherichia coli for aromatic amino acids by a tunable switch.Journal of industrial microbiology & biotechnology · 2020Article
- Complete genome sequence of3 Biotech · 2019Article
- Functional Genetic Elements for Controlling Gene Expression in Cupriavidus necator H16.Applied and environmental microbiology · 2018Article
- Leaderless mRNAs in the Spotlight: Ancient but Not Outdated!Microbiology spectrum · 2018Review
- Development of SimCells as a novel chassis for functional biosensors.Scientific reports · 2017Article
- Evolution of Dimethylsulfoniopropionate Metabolism in Marine Phytoplankton and Bacteria.Frontiers in microbiology · 2017Review
- Molecular Insight into the Acryloyl-CoA Hydration by AcuH for Acrylate Detoxification in Dimethylsulfoniopropionate-Catabolizing Bacteria.Frontiers in microbiology · 2017Article
- Genetically encoded sensors enable real-time observation of metabolite production.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Synthetic biosensors for precise gene control and real-time monitoring of metabolites.Nucleic acids research · 2015Article
- Screening of metagenomic and genomic libraries reveals three classes of bacterial enzymes that overcome the toxicity of acrylate.PloS one · 2014Article
- Acrylyl-coenzyme A reductase, an enzyme involved in the assimilation of 3-hydroxypropionate by Rhodobacter sphaeroides.Journal of bacteriology · 2013Article
- The TetR family of regulators.Microbiology and molecular biology reviews : MMBR · 2013Review
- Global mapping of transcription start sites and promoter motifs in the symbiotic α-proteobacterium Sinorhizobium meliloti 1021.BMC genomics · 2013Article
- A single missense mutation in a coiled-coil domain of Escherichia coli ribosomal protein S2 confers a thermosensitive phenotype that can be suppressed by ribosomal protein S1.Journal of bacteriology · 2013Article
- The architecture and ppGpp-dependent expression of the primary transcriptome of Salmonella Typhimurium during invasion gene expression.BMC genomics · 2012Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Rhodobacter sphaeroides strain 2.4.1 is a widely studied bacterium that has recently been shown to cleave the abundant marine anti-stress molecule dimethylsulfoniopropionate (DMSP) into acrylate plus gaseous dimethyl sulfide. It does so by using a lyase encoded by dddL, the promoter-distal gene of a three-gene operon, acuR-acuI-dddL. Transcription of the operon was enhanced when cells were pre-grown with the substrate DMSP, but this induction is indirect, and requires the conversion of DMSP to the product acrylate, the bona fide co-inducer. This regulation is mediated by the product of the promoter-proximal gene acuR, a transcriptional regulator in the TetR family. AcuR represses the operon in the absence of acrylate, but this is relieved by the presence of the co-inducer. Another unusual regulatory feature is that the acuR-acuI-dddL mRNA transcript is leaderless, such that acuR lacks a Shine-Dalgarno ribosomal binding site and 5'-UTR, and is translated at a lower level compared to the downstream genes. This regulatory unit may be quite widespread in bacteria, since several other taxonomically diverse lineages have adjacent acuR-like and acuI-like genes; these operons also have no 5' leader sequences or ribosomal binding sites and their predicted cis-acting regulatory sequences resemble those of R. sphaeroides acuR-acuI-dddL.
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