Evidence map›Paper›PMID 21249135›Full record

ArticlePloS one2011

High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons.

Satish L Deshmane, Ruma Mukerjee, Shongshan Fan, Bassel E Sawaya

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Caffeine Blocks HIV-1 Tat-Induced Amyloid Beta Production and Tau Phosphorylation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2017
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Role of p53 in neurodegenerative diseases.Neuro-degenerative diseases · 2012
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Satish L DeshmaneDepartment of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America.
Ruma Mukerjee
Shongshan Fan
Bassel E Sawaya
Temple University · US

Funding

Role of p53 family in neuropathogenesis in AIDSR01NS059327 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI SAWAYA, BASSEL E · 2008 to 2012
$1.9M
NINDS NIH HHS R01 NS059327NINDS NIH HHS R01NS059327
6 · The paper itself

Abstract

The HIV-1 protein, Tat has been implicated in AIDS pathogenesis however, the amount of circulating Tat is believed to be very low and its quantification has been difficult. We performed the quantification of Tat released from infected cells and taken up by neurons using high performance capillary electrophoresis. This is the first report to successfully measure the amount of Tat in neurons and places Tat as a key player involved in HIV-associated neurocognitive disorders.

Indexed as

AIDS Dementia ComplexCell CommunicationCell LineElectrophoresis, CapillaryGene Products, tatHIV-1HumansNeuronsGene Products, tat

Identifiers

PMID21249135
PMCPMC3017553
OpenAlexW2002158351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.