ArticleMucosal immunology2011
Key questions to guide a better understanding of host-commensal microbiota interactions in intestinal inflammation.
Article in Mucosal immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 76 citations in OpenAlex.
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- Gout drives metabolic dysfunction-associated steatotic liver disease through gut microbiota and inflammatory mediators.Scientific reports · 2025Article
- 2-Dodecyl-6-methoxycyclohexa-2,5-dien-1,4-dione alleviates liver fibrosis and improves intestinal flora and bile acid metabolism.Frontiers in pharmacology · 2025Article
- Metabolites mediate the causal associations between gut microbiota and NAFLD: a Mendelian randomization study.BMC gastroenterology · 2024Article
- Probiotic formulations and gastro-intestinal diseases in the paediatric population: a narrative review.Annals of medicine and surgery (2012) · 2024Review
- Group 3 innate lymphoid cells require BATF to regulate gut homeostasis in mice.The Journal of experimental medicine · 2022Article
- Stressor-Induced Increases in Circulating, but Not Colonic, Cytokines Are Related to Anxiety-like Behavior and Hippocampal Inflammation in a Murine Colitis Model.International journal of molecular sciences · 2022Article
- Butyrate producers, "The Sentinel of Gut": Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics.Frontiers in microbiology · 2022Review
- Habitual dietary intake of IBD patients differs from population controls: a case-control study.European journal of nutrition · 2021Article
- Supplementation of branched-chain amino acids decreases fat accumulation in the liver through intestinal microbiota-mediated production of acetic acid.Scientific reports · 2020Article
- Modulation of Gut Microbiota in Korean Navy Trainees following a Healthy Lifestyle Change.Microorganisms · 2020Article
- Weight loss is a sufficient and economical single outcome measure of murine dextran sulfate sodium colitis.FASEB bioAdvances · 2019Article
- Development of the Pediatric Gut Microbiome: Impact on Health and Disease.The American journal of the medical sciences · 2018Review
- Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance.Scientific reports · 2018Article
- Variability of core microbiota in newly diagnosed treatment-naïve paediatric inflammatory bowel disease patients.PloS one · 2018Article
- Ectopic Expression of Innate Immune Protein, Lipocalin-2, in Lactococcus lactis Protects Against Gut and Environmental Stressors.Inflammatory bowel diseases · 2017Article
- The Influence of the Gut Microbiota on Host Physiology: In Pursuit of Mechanisms.The Yale journal of biology and medicine · 2016Review
- Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome.Microbiome · 2016Article
- Diet, Microbiota, Obesity, and NAFLD: A Dangerous Quartet.International journal of molecular sciences · 2016Review
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Abstract
Co-evolution with an extremely complex commensal enteric microbiota has helped shape mammalian mucosal immune responses. A yet incompletely defined subset of intestinal bacteria is required to stimulate chronic, immune-mediated intestinal inflammation, including human Crohn's disease, and intestinal microbiota composition is altered in a characteristic manner by the inflammatory response to create a dysbiotic relationship of protective vs. aggressive bacteria. We pose a number of questions regarding host interactions with the enteric microbiota, including influences of inflammation, host genetics, early environmental exposure, and diet on microbial composition and function, and conversely, the effect of bacterial metabolism, enteric fungi and viruses, and endogenous protective bacterial species on host immune and inflammatory responses. These questions are designed to stimulate research that will promote a better understanding of host-microbial interactions in the intestine and promote targeted novel therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.