ArticleJournal of dental research2011
Cysteine cathepsins in human carious dentin.
Article in Journal of dental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed, 3 syntheses or guidelines pooled it, 230 citations in OpenAlex.
- Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies.Frontiers in cellular and infection microbiology · 2023Pooled it
- Evaluation of the efficiency of fluoride-releasing adhesives for preventing secondary caries in-vitro: a systematic review and meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2019Pooled it
- Mechanisms regulating the degradation of dentin matrices by endogenous dentin proteases and their role in dental adhesion. A review.American journal of dentistry · 2014Pooled it
- An Oral Rinse Active Matrix Metalloproteinase-8 Point-of-Care Immunotest May Be Less Accurate in Patients with Crohn's Disease.Biomolecules · 2020Trial
- Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2-Modulated Exosome Release.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Effect of magnetic MMP removal on long-term dentin collagen stability.European journal of oral sciences · 2026Article
- A Bioinspired Approach to Mechanically Reinforce Collagen-Rich Tissues Using Modularly Defined Stilbenoids.Biopolymers · 2026Article
- Caries status influence GCF MMP-9 in association with serum vitamin D: an exploratory retrospective cross-sectional study.BMC oral health · 2025Article
- Effects of Grape Seed Extract-Modified Etchants on Collagenolytic Activity, Interface Formation, and Bonding Longevity of Adhesive-Dentin Interfaces.Materials (Basel, Switzerland) · 2025Article
- Rapid detection of Lys-gingipain using fluorogenic peptide substrate for diagnosis of periodontitis.Journal of dental sciences · 2025Article
- Evolution of Dental Resin Adhesives-A Comprehensive Review.Journal of functional biomaterials · 2025Review
- Zymography as a Tool for Exploring Protease Activity in Dental Research.Methods in molecular biology (Clifton, N.J.) · 2025Article
- The activity, distribution, and colocalization of cathepsin K and matrix metalloproteases in intact and eroded dentin.Clinical oral investigations · 2023Article
- The Role of Bacterial, Dentinal, Salivary, and Neutrophil Degradative Activity in Caries Pathogenesis.Dentistry journal · 2023Review
- Dentin Degradation: From Tissue Breakdown to Possibilities for Therapeutic Intervention.Current oral health reports · 2023Article
- Degradation and Failure Phenomena at the Dentin Bonding Interface.Biomedicines · 2023Review
- Effects of protease inhibitors on dentin erosion: an in situ study.Clinical oral investigations · 2023Article
- Cathepsins in oral diseases: mechanisms and therapeutic implications.Frontiers in immunology · 2023Review
- Renewal MI Dental Composite Etch and Seal Properties.Materials (Basel, Switzerland) · 2022Article
- Salivary Enzymatic Activity and Carious Experience in Children: A Cross-Sectional Study.Children (Basel, Switzerland) · 2022Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
Matrix metalloproteinases (MMPs) are important in dentinal caries, and analysis of recent data demonstrates the presence of other collagen-degrading enzymes, cysteine cathepsins, in human dentin. This study aimed to examine the presence, source, and activity of cysteine cathepsins in human caries. Cathepsin B was detected with immunostaining. Saliva and dentin cysteine cathepsin and MMP activities on caries lesions were analyzed spectrofluorometrically. Immunostaining demonstrated stronger cathepsins B in carious than in healthy dentin. In carious dentin, cysteine cathepsin activity increased with increasing depth and age in chronic lesions, but decreased with age in active lesions. MMP activity decreased with age in both active and chronic lesions. Salivary MMP activities were higher in patients with active than chronic lesions and with increasing lesion depth, while cysteine cathepsin activities showed no differences. The results indicate that, along with MMPs, cysteine cathepsins are important, especially in active and deep caries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.