Trial reportJournal of dental research2011
Angiogenic biomarkers and healing of living cellular constructs.
Trial report in Journal of dental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Expression of Angiogenic Biomarkers During Healing of Intra-Oral Soft Tissue Engineered Grafts
Comparison of Envelope Coronally Advanced Flap and Modified Tunnel Technique in Soft Tissue Dehiscence Coverage Around Implants: A Randomized Clinical Trial
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Soft tissue substitutes in non-root coverage procedures: a systematic review and meta-analysis.Clinical oral investigations · 2017Pooled it
- Tissue Perfusion and Biomarkers Assessment Following Root Coverage Procedures.Journal of periodontal research · 2025Trial
- Evolution in the Peri-Implant Oral Microbiome and Their Relationship to Long-Term Marginal Bone Loss: A Randomized Clinical Study.Clinical oral implants research · 2025Trial
- Characterization of oral biomarkers during early healing at augmented dental implant sites.Journal of periodontal research · 2025Trial
- CEMP-1 Levels in Periodontal Wound Fluid during the Early Phase of Healing: Prospective Clinical Trial.Mediators of inflammation · 2019Trial
- Biomarkers during early healing of extraction procedures: a prospective case series.Clinical oral investigations · 2025Article
- Regenerative Endodontic Therapies: Harnessing Stem Cells, Scaffolds, and Growth Factors.Polymers · 2025Review
- Effect of Intermittent Hypobaric Hypoxia Exposure on HIF-1α, VEGF, and Angiogenesis in the Healing Process of Post-Tooth Extraction Sockets in Rats.European journal of dentistry · 2024Article
- Evaluation of platelet derived growth factor-BB levels in injectable platelet rich fibrin coated graft using gingival pedicle split thickness tunnel technique for isolated gingival recession: A randomized controlled trial.The Saudi dental journal · 2024Article
- Wound fluid sampling methods for proteomic studies: A scoping review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Article
- Effects of collagen membranes and bone substitute differ in periodontal ligament cell microtissues and monolayers.Journal of periodontology · 2022Article
- L-mimosine and hypoxia can increase angiogenin production in dental pulp-derived cells.BMC oral health · 2017Article
- Biochemical indicators of implantation success of tissue-engineered oral mucosa.Journal of dental research · 2015Article
- Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats.Nature communications · 2014Article
- Article
- Bone repair cells for craniofacial regeneration.Advanced drug delivery reviews · 2012Review
- Translational and clinical applications of salivary diagnostics.Advances in dental research · 2011Article
- Cell- and gene-based therapeutic strategies for periodontal regenerative medicine.Journal of periodontology · 2011Review
- Future Prospects for Periodontal Bioengineering Using Growth Factors.Clinical advances in periodontics · 2011Article
- Comparison of Attachment and Proliferation of Human Gingival Fibroblasts on Different Collagen Membranes.Annals of maxillofacial surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
The use of intra-oral soft-tissue-engineered devices has demonstrated potential for oral mucosa regeneration. The aim of this study was to investigate the temporal expression of angiogenic biomarkers during wound healing of soft tissue reconstructive procedures comparing living cellular constructs (LCC) with autogenous free gingival grafts. Forty-four human participants bilaterally lacking sufficient zones of attached keratinized gingiva were randomly assigned to soft tissue surgery plus either LCC or autograft. Wound fluid samples were collected at baseline and weeks 1, 2, 3, and 4 post-operatively and analyzed for a panel of angiogenic biomarkers: angiogenin (ANG), angiostatin (ANT), PDGF-BB, VEGF, FGF-2, IL-8, TIMP-1, TIMP-2, GM-CSF, and IP-10. Results demonstrated a significant increase in expression of ANT, PDGF-BB, VEGF, FGF-2, and IL-8 for the LCC group over the autograft group at the early stages of wound repair. Although angiogenic biomarkers were modestly elevated for the LCC group, no clinical correlation with wound healing was found. This human investigation demonstrates that, during early wound-healing events, expression of angiogenic-related biomarkers is up-regulated in sites treated with LCC compared with autogenous free gingival grafts, which may provide a safe and effective alternative for regenerating intra-oral soft tissues (ClinicalTrials.gov number, NCT01134081).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.