ArticleProceedings of the National Academy of Sciences of the United States of America2011
Myxobacteria gliding motility requires cytoskeleton rotation powered by proton motive force.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
91 citing papers in PubMed, 150 citations in OpenAlex.
- Antifungal metabolites fromRSC advances · 2026Article
- Distinct motors, shared mechanics: unifying principles of microbial gliding.Journal of bacteriology · 2026Review
- Optimized fermentation of Myxococcus fulvus WCH05 enhances biocontrol of pear fire blight in the field.BMC microbiology · 2026Article
- Bacterial motility in rhizosphere colonization: mechanisms, constraints, and implications for microbial inoculants.The ISME journal · 2026Review
- Milestones in the development ofJournal of bacteriology · 2025Review
- Article
- Structural model of a bacterial focal adhesion complex.Communications biology · 2025Article
- A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall.eLife · 2024Article
- A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall.bioRxiv : the preprint server for biology · 2024Article
- A deterministic, c-di-GMP-dependent program ensures the generation of phenotypically similar, symmetric daughter cells during cytokinesis.Nature communications · 2024Article
- A molecular switch controls assembly of bacterial focal adhesions.Science advances · 2024Article
- Repurposing 9-Aminoacridine as an Adjuvant Enhances the Antimicrobial Effects of Rifampin against Multidrug-Resistant Klebsiella pneumoniae.Microbiology spectrum · 2023Article
- Filamentous structures in the cell envelope are associated with bacteroidetes gliding machinery.Communications biology · 2023Article
- Mathematical modeling of mechanosensitive reversal control inFrontiers in microbiology · 2023Article
- Live Cell Imaging of Gliding Motility of Flavobacterium johnsoniae Under High-Resolution Microscopy.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Mechanical limitation of bacterial motility mediated by growing cell chains.Biophysical journal · 2022Article
- Bacterial motility: machinery and mechanisms.Nature reviews. Microbiology · 2022Review
- A noncanonical cytochromeProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Flagellar Motor Transformed: Biophysical Perspectives of theFrontiers in microbiology · 2022Article
- Conditional and Synthetic Type IV Pili-Dependent Motility Phenotypes inFrontiers in microbiology · 2022Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Myxococcus xanthus is a Gram-negative bacterium that glides over surfaces without the aid of flagella. Two motility systems are used for locomotion: social-motility, powered by the retraction of type IV pili, and adventurous (A)-motility, powered by unknown mechanism(s). We have shown that AgmU, an A-motility protein, is part of a multiprotein complex that spans the inner membrane and periplasm of M. xanthus. In this paper, we present evidence that periplasmic AgmU decorates a looped continuous helix that rotates clockwise as cells glide forward, reversing its rotation when cells reverse polarity. Inhibitor studies showed that the AgmU helix rotation is driven by proton motive force (PMF) and depends on actin-like MreB cytoskeletal filaments. The AgmU motility complex was found to interact with MotAB homologs. Our data are consistent with a mechanochemical model in which PMF-driven motors, similar to bacterial flagella stator complexes, run along an endless looped helical track, driving rotation of the track; deformation of the cell surface by the AgmU-associated proteins creates pressure waves in the slime, pushing cells forward.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.