ArticleMolecular biology of the cell2011
A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 69 citations in OpenAlex.
- Molecular machineries shaping the mitochondrial inner membrane.Nature reviews. Molecular cell biology · 2025Review
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- Protocol for engineering and validating a synthetic mitochondrial intermembrane bridge in mammalian cells.STAR protocols · 2022Article
- Mitochonic Acid 5 Improves Duchenne Muscular Dystrophy and Parkinson's Disease Model ofInternational journal of molecular sciences · 2022Article
- SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.Molecular metabolism · 2022Article
- Mitochondrial Dysfunction in Rabies Virus-Infected Human and Canine Brains.Neurochemical research · 2022Article
- Mitochondrial shape alteration by metabolites.Nature cell biology · 2022Article
- A feedback loop engaging propionate catabolism intermediates controls mitochondrial morphology.Nature cell biology · 2022Article
- Novel putative interactors of FZO-1/mitofusin 2 identified using large-scale yeast two-hybrid screening inmicroPublication biology · 2022Article
- Maintenance of complex I and its supercomplexes by NDUF-11 is essential for mitochondrial structure, function and health.Journal of cell science · 2021Article
- Effects of Aging on Expression ofAnimals : an open access journal from MDPI · 2020Article
- Mitochondrial Subtype Identification and Characterization.Current protocols in cytometry · 2018Article
- Cell Biology of the Mitochondrion.Genetics · 2017Review
- Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions.Nature communications · 2017Article
- A Select Subset of Electron Transport Chain Genes Associated with Optic Atrophy Link Mitochondria to Axon Regeneration inFrontiers in neuroscience · 2017Article
- High-Density Lipoprotein Regulation of Mitochondrial Function.Advances in experimental medicine and biology · 2017Review
- Developmentally programmed germ cell remodelling by endodermal cell cannibalism.Nature cell biology · 2016Article
- Identification and Characterization of Mitochondrial Subtypes in Caenorhabditis elegans via Analysis of Individual Mitochondria by Flow Cytometry.Analytical chemistry · 2016Article
- The Oxidation Status of Mic19 Regulates MICOS Assembly.Molecular and cellular biology · 2015Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Three proteins with similar effects on mitochondrial morphology were identified in an RNA interference (RNAi) screen for mitochondrial abnormalities in Caenorhabditis elegans. One of these is the novel mitochondrial outer membrane protein MOMA-1. The second is the CHCHD3 homologue, CHCH-3, a small intermembrane space protein that may act as a chaperone. The third is a mitofilin homologue, IMMT-1. Mitofilins are inner membrane proteins that control the shapes of cristae. RNAi or mutations in each of these genes change the relatively constant diameters of mitochondria into highly variable diameters, ranging from thin tubes to localized swellings. Neither growth nor brood size of the moma-1, chch-3, or immt-1 single mutants is affected, suggesting that their metabolic functions are normal. However, growth of moma-1 or immt-1 mutants on chch-3(RNAi) leads to withered gonads, a lack of mitochondrial staining, and a dramatic reduction in fecundity, while moma-1; immt-1 double mutants are indistinguishable from single mutants. Mutations in moma-1 and immt-1 also have similar effects on cristae morphology. We conclude that MOMA-1 and IMMT-1 act in the same pathway. It is likely that the observed effects on mitochondrial diameter are an indirect effect of disrupting cristae morphology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.