SynthesisThe American journal of clinical nutrition2011
Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals.
Synthesis in The American journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Pooled it
- Obesity-related genetic variants, human pigmentation, and risk of melanoma.Human genetics · 2013Trial
- Prevalence and Associated Factors of Overweight and Obesity among School-Aged Children in Zhuzhou, China.Obesity surgery · 2026Article
- Article
- MTCH2 in Metabolic Diseases, Neurodegenerative Diseases, Cancers, Embryonic Development and Reproduction.Drug design, development and therapy · 2024Review
- Opposing effects of genetic variation in MTCH2 for obesity versus heart failure.Human molecular genetics · 2023Article
- Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight.Human molecular genetics · 2022Article
- Association of theUpsala journal of medical sciences · 2020Article
- Article
- Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: a family-based study.BMC medical genetics · 2018Article
- Influence of Fetal and Maternal Genetic Susceptibility to Obesity on Birthweight in African Ancestry Populations.Frontiers in genetics · 2018Article
- Genetic association of FTO/IRX region with obesity and overweight in the Polish population.PloS one · 2017Article
- The importance of gene-environment interactions in human obesity.Clinical science (London, England : 1979) · 2016Review
- The impact of genetic variants on BMI increase during childhood versus adulthood.International journal of obesity (2005) · 2016Article
- A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP.Journal of human genetics · 2016Article
- Association between MC4R rs17782313 polymorphism and overeating behaviors.International journal of obesity (2005) · 2015Article
- Does FTO have a paradoxical effect in fetal life?BMC genetics · 2014Article
- Genetic risk score for prediction of newborn adiposity and large-for-gestational-age birth.The Journal of clinical endocrinology and metabolism · 2014Article
- The bigger picture of FTO: the first GWAS-identified obesity gene.Nature reviews. Endocrinology · 2014Review
- Fat mass and obesity-associated gene enhances oxidative stress and lipogenesis in nonalcoholic fatty liver disease.Digestive diseases and sciences · 2013Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundHigh birth weight is associated with adult body mass index (BMI). We hypothesized that birth weight and BMI may partly share a common genetic background.
objectiveThe objective was to examine the associations of 12 established BMI variants in or near the NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, BCDIN3D, SH2B1, FTO, MC4R, and KCTD15 genes and their additive score with birth weight.
designA meta-analysis was conducted with the use of 1) the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk, Hertfordshire, Fenland, and European Youth Heart Study cohorts (n(max) = 14,060); 2) data extracted from the Early Growth Genetics Consortium meta-analysis of 6 genome-wide association studies for birth weight (n(max) = 10,623); and 3) all published data (n(max) = 14,837).
resultsOnly the MTCH2 and FTO loci showed a nominally significant association with birth weight. The BMI-increasing allele of the MTCH2 variant (rs10838738) was associated with a lower birth weight (β ± SE: -13 ± 5 g/allele; P = 0.012; n = 23,680), and the BMI-increasing allele of the FTO variant (rs1121980) was associated with a higher birth weight (β ± SE: 11 ± 4 g/allele; P = 0.013; n = 28,219). These results were not significant after correction for multiple testing.
conclusionsObesity-susceptibility loci have a small or no effect on weight at birth. Some evidence of an association was found for the MTCH2 and FTO loci, ie, lower and higher birth weight, respectively. These findings may provide new insights into the underlying mechanisms by which these loci confer an increased risk of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.