ArticleJournal of leukocyte biology2011
SerpinB1 protects the mature neutrophil reserve in the bone marrow.
Article in Journal of leukocyte biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 61 citations in OpenAlex.
- A proteomic analysis of NETosis in trauma: Emergence of serpinB1 as a key player.The journal of trauma and acute care surgery · 2023Trial
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- SERPINB1 as a critical regulator of inflammation and protease activity in human monocytic cells.ImmunoHorizons · 2026Article
- Immature Neutrophil Phenotype and Enhanced Myeloperoxidase in Male Patients With Chronic Kidney Disease and Cardiovascular Comorbidity.Acta physiologica (Oxford, England) · 2026Article
- The 24-Hour Leukocyte Gap as a novel predictor for sepsis in adult severe blunt trauma.Langenbeck's archives of surgery · 2025Article
- Increased circulating serpinB1 levels in children with overweight/obesity are associated with obesity-related parameters: a cross‑sectional study.BMC pediatrics · 2024Article
- LineageVAE: reconstructing historical cell states and transcriptomes toward unobserved progenitors.Bioinformatics (Oxford, England) · 2024Article
- Five genes as diagnostic biomarkers of dermatomyositis and their correlation with immune cell infiltration.Frontiers in immunology · 2023Article
- Integrated Proteotranscriptomics Reveals Differences in Molecular Immunity between Min and Large White Pig Breeds.Biology · 2022Article
- Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection.The Journal of clinical investigation · 2022Article
- SERPINB1 overexpression protects myocardial damage induced by acute myocardial infarction through AMPK/mTOR pathway.BMC cardiovascular disorders · 2022Article
- ITRAQ-based quantitative proteomics analysis of forest musk deer with pneumonia.Frontiers in veterinary science · 2022Article
- Shift of Neutrophils From Blood to Bone Marrow Upon Extensive Experimental Trauma Surgery.Frontiers in immunology · 2022Article
- Neutrophils: Need for Standardized Nomenclature.Frontiers in immunology · 2021Review
- Neutrophils-From Bone Marrow to First-Line Defense of the Innate Immune System.Frontiers in immunology · 2021Review
- Protein and Microbial Biomarkers in Sputum Discern Acute and Latent Tuberculosis in Investigation of Pastoral Ethiopian Cohort.Frontiers in cellular and infection microbiology · 2021Article
- Serpinb1a Is Dispensable for the Development and Cytokine Response of Invariant Natural Killer T Cell Subsets.Frontiers in immunology · 2020Article
- SerpinB1 controls encephalitogenic T helper cells in neuroinflammation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.Cell reports · 2019Article
- Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia.Journal of molecular medicine (Berlin, Germany) · 2019Article
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6 authors at 2 institutions in 2 countries.
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Abstract
SerpinB1 is among the most efficient inhibitors of neutrophil serine proteases--NE, CG, and PR-3--and we investigated here its role in neutrophil development and homeostasis. We found that serpinB1 is expressed in all human bone marrow leukocytes, including stem and progenitor cells. Expression levels were highest in the neutrophil lineage and peaked at the promyelocyte stage, coincident with the production and packaging of the target proteases. Neutrophil numbers were decreased substantially in the bone marrow of serpinB1(-/-) mice. This cellular deficit was associated with an increase in serum G-CSF levels. On induction of acute pulmonary injury, neutrophils were recruited to the lungs, causing the bone marrow reserve pool to be completely exhausted in serpinB1(-/-) mice. Numbers of myeloid progenitors were normal in serpinB1(-/-) bone marrow, coincident with the absence of target protease expression at these developmental stages. Maturation arrest of serpinB1(-/-) neutrophils was excluded by the normal CFU-G growth in vitro and the normal expression in mature neutrophils of early and late differentiation markers. Normal absolute numbers of proliferating neutrophils and pulse-chase kinetic studies in vivo showed that the bone marrow deficit in serpinB1(-/-) mice was largely restricted to mature, postmitotic neutrophils. Finally, upon overnight culture, apoptosis and necrosis were greater in purified bone marrow neutrophils from serpinB1(-/-) compared with WT mice. Collectively, these findings demonstrate that serpinB1 sustains a healthy neutrophil reserve that is required in acute immune responses.
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