ArticleEndocrinology2011
Sox3 functions in a cell-autonomous manner to regulate spermatogonial differentiation in mice.
Article in Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Diverse SOX3 genetic variants and their associated phenotypic spectrum in human disease.Endocrine reviews · 2026Review
- RUNX proteins and CBFβ create an interconnected network of transcriptional regulation in the male germline†.Biology of reproduction · 2026Article
- ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network.Nature structural & molecular biology · 2025Article
- Review
- Characterization of the transcription factor Sox3 regulating the gonadal development of pearlscale angelfish (Centropyge vrolikii).Fish physiology and biochemistry · 2022Article
- Identification of an SRY-negative 46,XX infertility male with a heterozygous deletion downstream of SOX3 gene.Molecular cytogenetics · 2022Article
- Sheng Jing Decoction Can Promote Spermatogenesis and Increase Sperm Motility of the Oligozoospermia Mouse Model.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Review
- SOX3 promotes generation of committed spermatogonia in postnatal mouse testes.Scientific reports · 2020Article
- Developmental kinetics and transcriptome dynamics of stem cell specification in the spermatogenic lineage.Nature communications · 2019Article
- SOX3 can promote the malignant behavior of glioblastoma cells.Cellular oncology (Dordrecht, Netherlands) · 2019Article
- Expression profiles of Sox transcription factors within the postnatal rodent testes.Molecular and cellular biochemistry · 2018Article
- Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes.Development (Cambridge, England) · 2018Article
- Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements.BMC biology · 2018Article
- UXT is required for spermatogenesis in mice.PloS one · 2018Article
- Knockdown of SOX2OT inhibits the malignant biological behaviors of glioblastoma stem cells via up-regulating the expression of miR-194-5p and miR-122.Molecular cancer · 2017Article
- Mettl3-/Mettl14-mediated mRNA NCell research · 2017Article
- Sex-determining region Y-box3 (SOX3) functions as an oncogene in promoting epithelial ovarian cancer by targeting Src kinase.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes.Development (Cambridge, England) · 2016Article
- The Role of Retinoic Acid (RA) in Spermatogonial Differentiation.Biology of reproduction · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The X-linked Sox3 gene encodes a member of the Sry high-mobility group box proteins, which play a role in many developmental processes including neurogenesis and testis development. This study further examined the role of Sox3 in spermatogenesis. Males without Sox3 expression exhibited a similar number of germ cell nuclear antigen-positive germ cells at 1, 5, and 10 d postpartum (dpp) compared to their wild-type littermates, but there was significant germ cell depletion by 20 dpp. However, spermatogenesis later resumed and postmeiotic germ cells were observed by 56 dpp. The VasaCre transgene was used to generate a germ cell-specific deletion of Sox3. The phenotype of the germ cell-specific Sox3 knockout was similar to the ubiquitous knockout, indicating an intrinsic role for Sox3 in germ cells. The residual germ cells in 20 dpp Sox3(-/Y) males were spermatogonia as indicated by their expression of neurogenin3 but not synaptonemal complex protein 3, which is expressed within cells undergoing meiosis. RNA expression analyses corroborated the histological analyses and revealed a gradual transition from relatively increased expression of spermatogonia genes at 20 dpp to near normal expression of genes characteristic of undifferentiated and meiotic germ cells by 84 dpp. Fluorescent-activated cell sorting of undifferentiated (ret tyrosine kinase receptor positive) and differentiated (kit receptor tyrosine kinase-positive) spermatogonia revealed depletion of differentiated spermatogonia in Sox3(-/Y) tubules. These results indicate that Sox3 functions in an intrinsic manner to promote differentiation of spermatogonia in prepubertal mice but it is not required for ongoing spermatogenesis in adults. The Sox3(-/Y) males provide a unique model for studying the mechanism of germ cell differentiation in prepubertal testes.
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