ArticleEndocrinology2011
Effect of animal facility construction on basal hypothalamic-pituitary-adrenal and renin-aldosterone activity in the rat.
Article in Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
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- Chronic Unpredictable Mild Stress Model of Depression: Possible Sources of Poor Reproducibility and Latent Variables.Biology · 2022Review
- Evaluation of Ambient Sound, Vibration, and Light in Rodent Housing Rooms.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- An assessment of ambient noise and other environmental variables in a nonhuman primate housing facility.Lab animal · 2022Article
- Effect of ACE, ACE2 and CYP11B2 gene polymorphisms and noise on essential hypertension among steelworkers in China: a case-control study.BMC medical genomics · 2022Article
- Noise and Vibration in the Vivarium: Recommendations for Developing a Measurement Plan.Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Vibration in mice: A review of comparative effects and use in translational research.Animal models and experimental medicine · 2018Review
- A users guide to HPA axis research.Physiology & behavior · 2017Review
- Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice.Scientific reports · 2017Article
- Effect of Interaction Between Noise and A1166C Site of AT1R Gene Polymorphism on Essential Hypertension in an Iron and Steel Enterprise Workers.Journal of occupational and environmental medicine · 2017Article
- Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design.FEMS microbiology reviews · 2016Review
- Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Fighting in the home cage: Agonistic encounters and effects on neurobiological markers within the social decision-making network of house mice (Mus musculus).Neuroscience letters · 2014Article
- Mortality and morbidity in African clawed frogs (Xenopus laevis) associated with construction noise and vibrations.Journal of the American Association for Laboratory Animal Science : JAALAS · 2012Article
- Corncob bedding alters the effects of estrogens on aggressive behavior and reduces estrogen receptor-α expression in the brain.Endocrinology · 2012Article
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5 authors at 3 institutions in 1 country.
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Abstract
Although loud noise and intense vibration are known to alter the behavior and phenotype of laboratory animals, little is known about the effects of nearby construction. We studied the effect of a nearby construction project on the classic stress hormones ACTH, corticosterone, renin, and aldosterone in rats residing in a barrier animal facility before, for the first 3 months of a construction project, and at 1 month after all construction was completed. During some of the construction, noise and vibrations were not obvious to investigators inside the animal rooms. Body weight matched for age was not altered by nearby construction. During nearby construction, plasma ACTH, corticosterone, and aldosterone were approximately doubled compared with those of pre- and postconstruction levels. Expression of CRH mRNA in the paraventricular nucleus of the hypothalamus, CRH receptor and POMC mRNA in the anterior pituitary, and most mRNAs for steroidogenic genes in the adrenal gland were not significantly changed during construction. We conclude that nearby construction can cause a stress response without long-term effects on hypothalamic-pituitary-adrenal axis gene expression and body weight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.