Evidence map›Paper›PMID 21248092›Full record

ArticleJournal of clinical microbiology2011

Direct genotyping of Toxoplasma gondii in ocular fluid samples from 20 patients with ocular toxoplasmosis: predominance of type II in France.

A Fekkar, D Ajzenberg, B Bodaghi, F Touafek, P Le Hoang, J Delmas, P Y Robert, M L Dardé, D Mazier, L Paris

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Frontiers in cellular and infection microbiology · 2022
    Review
  6. Seroprevalence and Genetic Characterization ofJournal of tropical medicine · 2022
    Article
  7. Frontiers in cellular and infection microbiology · 2021
    Article
  8. Review
  9. Article
  10. Article
  11. Serotyping ofFrontiers in cellular and infection microbiology · 2019
    Article
  12. A Retrospective Observational Study of Uveitis in a Single Center in Poland with a Review of Findings in Europe.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Observational
  13. Direct genetic characterization of Toxoplasma gondii from clinical samples from Denmark: not only genotypes II and III.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018
    Article
  14. Article
  15. Article
  16. Experimental Models of Ocular Infection with Toxoplasma Gondii.European journal of microbiology & immunology · 2015
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

A FekkarAP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service Parasitologie-Mycologie, Paris F-75013 France. arnaud.fekkar@psl.aphp.fr
D Ajzenberg
B Bodaghi
F Touafek
P Le Hoang
J Delmas
P Y Robert
M L Dardé
D Mazier
L Paris
Sorbonne Université · FRAssistance Publique – Hôpitaux de Paris · FRHôpital Universitaire Dupuytren · FRUniversité de Limoges · FRPitié-Salpêtrière Hospital · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the direct genotyping analysis of Toxoplasma gondii in ocular samples collected from 20 patients, as well as associated clinical and epidemiological data. This work was aimed at better understanding the impact of genotypes of Toxoplasma gondii strains on toxoplasmic retinochoroiditis. For this purpose, we studied the aqueous humor (AH) or vitreous humor (VH) of 20 patients presenting with ocular toxoplasmosis (OT) in 2 hospitals in France. Genetic characterization was obtained with microsatellite markers in a multiplex PCR assay. In contrast to the results of previous studies, we found no association between atypical Toxoplasma gondii genotypes and the occurrence of OT. Considering the local epidemiological data, our OT patients seemed to be infected more frequently by ordinary type II strains found in the environment. In conclusion, direct genotyping of Toxoplasma gondii strains from aqueous or vitreous humor showed a predominance of the type II genotype in ocular toxoplasmosis; this may be due to a high exposure rate of this genotype in humans.

Indexed as

AdultAgedAged, 80 and overAqueous HumorDNA, ProtozoanFemaleFranceGenotypeHumansMaleMicrosatellite RepeatsMiddle AgedMolecular EpidemiologyPolymerase Chain ReactionToxoplasmaToxoplasmosis, OcularDNA, Protozoan

Identifiers

PMID21248092
PMCPMC3122785
OpenAlexW2139711081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.