ArticleJournal of clinical microbiology2011
Outbreak of infections by hepatitis B virus genotype A and transmission of genetic drug resistance in patients coinfected with HIV-1 in Japan.
Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Prevalence of Anal Human Papillomavirus Infection and Risk Factors among HIV-positive Patients in Tokyo, Japan.PloS one · 2015Trial
- Article
- Hepatitis B Virus Genotype G: The Odd Cousin of the Family.Frontiers in microbiology · 2022Review
- Review
- Increased risk of non-AIDS-defining cancers in Asian HIV-infected patients: a long-term cohort study.BMC cancer · 2018Article
- Virological and Clinical Characteristics of Hepatitis B Virus Genotype A.Journal of gastroenterology · 2018Review
- Hepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flows.PloS one · 2018Article
- Clinical and biological insights from viral genome sequencing.Nature reviews. Microbiology · 2017Review
- Hepatitis B virus and its sexually transmitted infection - an update.Microbial cell (Graz, Austria) · 2016Review
- Article
- Viral hepatitis and human immunodeficiency virus co-infections in Asia.World journal of virology · 2015Review
- Article
- Recent population expansions of hepatitis B virus in the United States.Journal of virology · 2014Article
- Enigmatic origin of hepatitis B virus: an ancient travelling companion or a recent encounter?World journal of gastroenterology · 2014Review
- Prevalence of Hepatitis B Co-Infection among HIV Positive Patients: Narrative Review Article.Iranian journal of public health · 2014Review
- High diversity of hepatitis B virus genotypes in Panamanian blood donors: a molecular analysis of new variants.PloS one · 2014Article
- Drug-resistance associated mutations in polymerase (p) gene of hepatitis B virus isolated from malaysian HBV carriers.Hepatitis monthly · 2014Article
- Prevalence and epidemiological traits of HIV infections in populations with high-risk behaviours as revealed by genetic analysis of HBV.Epidemiology and infection · 2013Article
- Hepatitis B virus reactivation associated with temozolomide for malignant glioma: a case report and recommendation for prophylaxis.International journal of clinical oncology · 2012Article
- Is there any value to hepatitis B virus genotype analysis?Current gastroenterology reports · 2012Review
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major routes of hepatitis B virus (HBV) infection in Japan has been mother-to-child transmission (MTCT) and blood transfusion. However, HBV cases transmitted through sexual contact are increasing, especially among HIV-1-seropositive patients. To understand the molecular epidemiology of HBV in HBV/HIV-1 coinfection, we analyzed HBV genotypes and HIV-1 subtypes in HBV/HIV-1-coinfected patients at Nagoya Medical Center from 2003 to 2007. Among 394 HIV-1-infected Japanese men having sex with men (MSM) who were newly diagnosed during the study period, 31 (7.9%) tested positive for the hepatitis B virus surface antigen. HBV sequence analyses were successful in 26 cases, with 21 (80.7%) and 5 (19.3%) cases determined as genotypes A and C, respectively. Our finding that HBV genotype A was dominant in HIV-1-seropositive patients alerts clinicians to an alternative outbreak of HBV genotype A in the HIV-1-infected MSM population and a shift in HBV genotype from C to A in Japan. The narrow genetic diversity in genotype A cases suggests that genotype A has been recently introduced into the MSM population and that sexual contacts among MSM were more active than speculated from HIV-1 tree analyses. In addition, we found a lamivudine resistance mutation in one naïve case, suggesting a risk of drug-resistant HBV transmission. As genotype A infection has a higher risk than infection with other genotypes for individuals to become HBV carriers, prevention programs are urgently needed for the target population.
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