ArticlePlant physiology2011
Coexpression-based clustering of Arabidopsis root genes predicts functional modules in early phosphate deficiency signaling.
Article in Plant physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 140 citations in OpenAlex.
- Uracil-DNA Glycosylase fromInternational journal of molecular sciences · 2025Article
- Association mapping for root system architecture under varying levels of phosphorus application in Brassica juncea L. Czern & Coss.BMC genomics · 2025Article
- Effects of arbuscular mycorrhizal fungi on the current generation and offspring of host plant Medicago truncatula under low-P environment.BMC plant biology · 2025Article
- Transcriptomic Response of White Lupin Roots to Short-Term Sucrose Treatment.Plants (Basel, Switzerland) · 2025Article
- Arabidopsis PROTODERMAL FACTOR2 binds lysophosphatidylcholines and transcriptionally regulates phospholipid metabolism.The New phytologist · 2024Article
- Phosphate starvation regulates cellulose synthesis to modify root growth.Plant physiology · 2024Article
- Genome-wide identification of the WRKY gene family inFrontiers in plant science · 2023Article
- Alkalinity modulates a unique suite of genes to recalibrate growth and pH homeostasis.Frontiers in plant science · 2023Article
- Combined Approach of GWAS and Phylogenetic Analyses to Identify New Candidate Genes That Participate inPlants (Basel, Switzerland) · 2022Article
- Phosphate transporter PHT1;1 is a key determinant of phosphorus acquisition in Arabidopsis natural accessions.Plant physiology · 2022Article
- Spatial origin of the extracellular ATP-induced cytosolic calcium signature in Arabidopsis thaliana roots: wave formation and variation with phosphate nutrition.Plant biology (Stuttgart, Germany) · 2022Article
- Arabinogalactan Proteins: Focus on the Role in Cellulose Synthesis and Deposition during Plant Cell Wall Biogenesis.International journal of molecular sciences · 2022Review
- Hypoxia-Induced Aquaporins and Regulation of Redox Homeostasis by a Trans-Plasma Membrane Electron Transport System in Maize Roots.Antioxidants (Basel, Switzerland) · 2022Article
- An improved repertoire of splicing variants and their potential roles in Arabidopsis photomorphogenic development.Genome biology · 2022Article
- Comprehensive In Silico Analysis and Transcriptional Profiles Highlight the Importance of Mitochondrial Dicarboxylate Carriers (DICs) on Hypoxia Response in BothPlants (Basel, Switzerland) · 2022Article
- Noncoding RNAs responsive to nitric oxide and their protein-coding gene targets shed light on root hair formation inFrontiers in genetics · 2022Article
- Ethylene Response Factor109 Attunes Immunity, Photosynthesis, and Iron Homeostasis in Arabidopsis Leaves.Frontiers in plant science · 2022Article
- Phosphate-deprivation and damage signalling by extracellular ATP.Frontiers in plant science · 2022Article
- The versatility of plant organic acid metabolism in leaves is underpinned by mitochondrial malate-citrate exchange.The Plant cell · 2021Article
- Transcriptome provides potential insights into how calcium affects the formation of stone cell in Pyrus.BMC genomics · 2021Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphate (Pi) deficiency triggers the differential expression of a large set of genes, which communally adapt the plant to low Pi bioavailability. To infer functional modules in early transcriptional responses to Pi deficiency, we conducted time-course microarray experiments and subsequent coexpression-based clustering of Pi-responsive genes by pairwise comparison of genes against a customized database. Three major clusters, enriched in genes putatively functioning in transcriptional regulation, root hair formation, and developmental adaptations, were predicted from this analysis. Validation of gene expression by quantitative reverse transcription-PCR revealed that transcripts from randomly selected genes were robustly induced within the first hour after transfer to Pi-deplete medium. Pectin-related processes were among the earliest and most robust responses to Pi deficiency, indicating that cell wall alterations are critical in the early transcriptional response to Pi deficiency. Phenotypical analysis of homozygous mutants defective in the expression of genes from the root hair cluster revealed eight novel genes involved in Pi deficiency-induced root hair elongation. The plants responded rapidly to Pi deficiency by the induction of a subset of transcription factors, followed by a repression of genes involved in cell wall alterations. The combined results provide a novel, integrated view at a systems level of the root responses that acclimate Arabidopsis (Arabidopsis thaliana) to suboptimal Pi levels.
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