ArticleNucleic acids research2011
Genome-wide profiling of forum domains in Drosophila melanogaster.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- CBP and RAD21 Proteins Bind at the Termini of Forum Domains in Human Chromosomes.Doklady. Biochemistry and biophysics · 2023Article
- Genes Possessing the Most Frequent DNA DSBs Are Highly Associated with Development and Cancers, and Essentially Overlap with the rDNA-Contacting Genes.International journal of molecular sciences · 2022Article
- Single nucleotide-level mapping of DNA double-strand breaks in human HEK293T cells.Genomics data · 2017Article
- Hot spots of DNA double-strand breaks in human rDNA units are produced in vivo.Scientific reports · 2016Article
- Genome-wide mapping of hot spots of DNA double-strand breaks in human cells as a tool for epigenetic studies and cancer genomics.Genomics data · 2015Article
- Hot spots of DNA double-strand breaks and genomic contacts of human rDNA units are involved in epigenetic regulation.Journal of molecular cell biology · 2015Article
- Mapping of genomic double-strand breaks by ligation of biotinylated oligonucleotides to forum domains: Analysis of the data obtained for human rDNA units.Genomics data · 2015Article
- Genome-wide study of correlations between genomic features and their relationship with the regulation of gene expression.DNA research : an international journal for rapid publication of reports on genes and genomes · 2015Article
- Analysis of genome-wide contacts of forum terminus in Drosophila S2 cells.Doklady. Biochemistry and biophysics · 2013Article
- DNA double-strand breaks coupled with PARP1 and HNRNPA2B1 binding sites flank coordinately expressed domains in human chromosomes.PLoS genetics · 2013Article
- Analysis of insulator proteins binding in reporter genetic constructs transfected into Drosophila S2 cells.Doklady. Biochemistry and biophysicsArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Forum domains are stretches of chromosomal DNA that are excised from eukaryotic chromosomes during their spontaneous non-random fragmentation. Most forum domains are 50-200 kb in length. We mapped forum domain termini using FISH on polytene chromosomes and we performed genome-wide mapping using a Drosophila melanogaster genomic tiling microarray consisting of overlapping 3 kb fragments. We found that forum termini very often correspond to regions of intercalary heterochromatin and regions of late replication in polytene chromosomes. We found that forum domains contain clusters of several or many genes. The largest forum domains correspond to the main clusters of homeotic genes inside BX-C and ANTP-C, cluster of histone genes and clusters of piRNAs. PRE/TRE and transcription factor binding sites often reside inside domains and do not overlap with forum domain termini. We also found that about 20% of forum domain termini correspond to small chromosomal regions where Ago1, Ago2, small RNAs and repressive chromatin structures are detected. Our results indicate that forum domains correspond to big multi-gene chromosomal units, some of which could be coordinately expressed. The data on the global mapping of forum domains revealed a strong correlation between fragmentation sites in chromosomes, particular sets of mobile elements and regions of intercalary heterochromatin.
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