ArticleNucleic acids research2011
Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Super-enhancer omics in stem cell.Molecular cancer · 2024Review
- Stem Cell-Derived Exosomal MicroRNAs as Novel Potential Approach for Multiple Sclerosis Treatment.Cellular and molecular neurobiology · 2024Review
- Review
- Inter-regulatory role of microRNAs in interaction between viruses and stem cells.World journal of stem cells · 2021Review
- Article
- microRNAs: important regulators of stem cells.Stem cell research & therapy · 2017Review
- Alcohol effects on the epigenome in the germline: Role in the inheritance of alcohol-related pathology.Alcohol (Fayetteville, N.Y.) · 2017Review
- The miR-290-295 cluster as multi-faceted players in mouse embryonic stem cells.Cell & bioscience · 2017Review
- Article
- Early maternal alcohol consumption alters hippocampal DNA methylation, gene expression and volume in a mouse model.PloS one · 2015Article
- Role of CTCF in the regulation of microRNA expression.Frontiers in genetics · 2012Article
- Transcription factor binding sites are highly enriched within microRNA precursor sequences.Biology direct · 2011Article
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Authors and funding
4 authors.
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Abstract
The miR-290 cluster is expressed in embryonic stem cells (ESCs) and is important for the maintenance of pluripotency, but little is known about the mechanisms regulating the early embryonic microRNA cluster (EEmiRC) expression. Here we report the identification of a 332-bp intragenic enhancer (IE) able to modulate the transcription of the mouse EEmiRC locus, presumably through binding of transcription modulators like Oct3/4, Sox2 and CTCF. This IE also contains a CpG island showing a differential pattern of DNA and histone methylation marks during differentiation of ESCs, which places EEmiRC in a novel regulatory feedback loop with DNA methylases. Deletion of IE significantly reduced the transcription of the EEmiRC, further proving the importance of this region in regulating the expression of EEmiRC.
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