ArticleCancer epidemiology2011
Mammographic density and hormone receptor expression in breast cancer: the Multiethnic Cohort Study.
Article in Cancer epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mammographic density and risk of breast cancer by age and tumor characteristics.Breast cancer research : BCR · 2013Pooled it
- Association of Breast Density with Breast Cancer Risk and Stage at Diagnosis: A Korean Nationwide Cohort Study.Cancers · 2025Article
- Mammographic density and breast cancer risk among Black American women.International journal of cancer · 2025Article
- Association between mammographic breast density and outcome in patients with unilateral invasive breast cancer receiving neoadjuvant chemotherapy.Breast cancer research and treatment · 2025Observational
- Association of mammographic breast density measurements and hormone receptor status of breast cancer.Polish journal of radiology · 2024Article
- Correlation of Breast Density Grade on Mammogram With Diagnosed Breast Cancer: A Retrospective Cross-Sectional Study.Cureus · 2022Article
- Deep learning identification of stiffness markers in breast cancer.Biomaterials · 2022Article
- The Relationship Between Mammographic Density and Factors Affecting Breast Cancer Risk.Sisli Etfal Hastanesi tip bulteni · 2022Article
- Prediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density.Scientific reports · 2021Article
- A review of the influence of mammographic density on breast cancer clinical and pathological phenotype.Breast cancer research and treatment · 2019Review
- Mammographic density parameters and breast cancer tumor characteristics among postmenopausal women.Breast cancer (Dove Medical Press) · 2019Article
- Article
- Risk Factors That Increase Risk of Estrogen Receptor-Positive and -Negative Breast Cancer.Journal of the National Cancer Institute · 2017Article
- Background Parenchymal Enhancement and Fibroglandular Tissue Proportion on Breast MRI: Correlation with Hormone Receptor Expression and Molecular Subtypes of Breast Cancer.The journal of breast health · 2017Article
- Mammographic density and breast cancer in women from high risk families.Breast cancer research : BCR · 2015Article
- Dense and nondense mammographic area and risk of breast cancer by age and tumor characteristics.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
- Tumor phenotype and breast density in distinct categories of interval cancer: results of population-based mammography screening in Spain.Breast cancer research : BCR · 2014Article
- Biological characteristics of interval cancers: a role for biomarkers in the breast cancer screening.Journal of cancer research and clinical oncology · 2013Article
- Mammographic Density and Prediction of Nodal Status in Breast Cancer Patients.Geburtshilfe und Frauenheilkunde · 2013Article
- Mammographic density and risk of breast cancer according to tumor characteristics and mode of detection: a Spanish population-based case-control study.Breast cancer research : BCR · 2013Article
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4 authors.
Funding
Abstract
backgroundIt is unclear whether mammographic breast density, a strong risk factor for breast cancer, predicts subtypes of breast cancer defined by estrogen receptor (ER) and/or progesterone receptor (PR) expression.
methodsIn a nested case-control study, we compared the breast density of 667 controls and 607 breast cancer cases among women of Caucasian, Japanese, and Native Hawaiian ancestry in the Hawaii component of the Multiethnic Cohort Study. A reader blinded to disease status performed computer assisted density assessment on prediagnostic mammograms. Receptor status was obtained from the statewide Hawaii Tumor Registry. Tumors were classified into ER+PR+ (n=341), ER-PR- (n=50), ER+PR-/ER-PR+ (n=64), and unstaged/unknown (n=152). Mean percent density values were computed for women with more than one mammogram. Polytomous logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) while adjusting for confounders.
resultsMean percent density was significantly greater for ER+PR+ but not for ER-PR- tumors compared to controls after adjusting for age: 37.3%, 28.9% versus 29.4%, respectively. The overall OR per 10% increase in percent density were similar for ER+PR+ and ER+PR-/ER-PR+ tumors: 1.26 (95% CI 1.17-1.36) and 1.23 (95% CI 1.07-1.42), respectively. However, percent density was not found to be a predictor for ER-PR- tumors (OR 1.00, 95% CI 0.84-1.18). The results did not differ by ethnicity, nor by menopausal status, parity, or HRT use.
conclusionsOur findings indicate that within a multiethnic population, women with higher breast density have an increased risk for ER+PR+ but not ER-PR- tumors.
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