ArticleBMC musculoskeletal disorders2011
Effect of training and sudden detraining on the patellar tendon and its enthesis in rats.
Article in BMC musculoskeletal disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural Variations of Tendons: A Systematic Search and Narrative Review of Histological Differences Between Tendons, Tendon Regions, Sex, and Age.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Pooled it
- Functional anatomy of entheses and enthesis organs: A celebration of Professor Mike Benjamin's contribution to enthesis biology.Journal of anatomy · 2026Review
- Effectiveness of Ultrasound-Guided Peritendinous Injection Treatment with Low Molecular Weight Hyaluronic Acid in Patients with Supraspinatus Tendinopathy.Journal of clinical medicine · 2025Article
- Characterization of the mechanical properties of the mouse Achilles tendon enthesis by microindentation. Effects of unloading and subsequent reloading.Bone reports · 2024Article
- The tendon unit: biochemical, biomechanical, hormonal influences.Journal of orthopaedic surgery and research · 2023Review
- The Role of the Non-Collagenous Extracellular Matrix in Tendon and Ligament Mechanical Behavior: A Review.Journal of biomechanical engineering · 2022Review
- Low Molecular Weight Hyaluronic Acid (500-730 Kda) Injections in Tendinopathies-A Narrative Review.Journal of functional morphology and kinesiology · 2021Review
- [Status and treatment of knee extension device disruption after total knee arthroplasty].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2021Article
- Inhibition of ERK 1/2 kinases prevents tendon matrix breakdown.Scientific reports · 2021Article
- Detraining and Anabolic-Androgenic Steroid Discontinuation Change Calcaneal Tendon Morphology.Journal of functional morphology and kinesiology · 2018Article
- The effects of detraining and training on adipose tissue lipid droplet in obese mice after chronic high-fat diet.Lipids in health and disease · 2017Article
- The Role of Detraining in Tendon Mechanobiology.Frontiers in aging neuroscience · 2016Review
- Complications involving the extensor mechanism after total knee arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Review
- Impact of oestrogen deficiency and aging on tendon: concise review.Muscles, ligaments and tendons journal · 2014Review
- Effectiveness of the Intratissue Percutaneous Electrolysis (EPI®) technique and isoinertial eccentric exercise in the treatment of patellar tendinopathy at two years follow-up.Muscles, ligaments and tendons journal · 2014Article
- The effects of an early return to training on the bone-tendon junction post-acute micro-injury healing.Journal of sports science & medicine · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferent conditions may alter tendon characteristics. Clinical evidence suggests that tendon injuries are more frequent in athletes that change type, intensity and duration of training. Aim of the study was the assessment of training and especially detraining on the patellar tendon (PT) and its enthesis.
methods27 male adult Sprague-Dawley rats were divided into 3 groups: 20 rats were trained on a treadmill for 10 weeks. Of these, 10 rats were euthanized immediately after training (trained group), and 10 were caged without exercise for 4 weeks before being euthanized (de-trained group). The remaining 7 rats were used as controls (untrained rats). PT insertion, structure (collagen fiber organization and proteoglycan, PG, content), PT thickness, enthesis area, and subchondral bone volume at the enthesis were measured by histomorphometry and microtomography.
resultsBoth PG content and collagen fiber organization were significantly lower in untrained and detrained animals than in trained ones (p < 0.05 and p < 0.0001). In the detrained group, fiber organization and PG content were worse than that of the untrained groups and the untrained group showed a significantly higher score than the detrained group (p < 0.05). In the trained group, the PT was significantly thicker than in untrained group (p < 0.05). No significant differences in the enthesis area and subchondral bone volume among the three groups were seen.
conclusionsModerate exercise exerts a protective effect on the PT structure while sudden discontinuation of physical activity has a negative effect on tendons. The present results suggest that after a period of sudden de-training (such as after an injury) physical activity should be restarted with caution and with appropriate rehabilitation programs.
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