ArticleAnalytical chemistry2011
Photothermal nanoblade for large cargo delivery into mammalian cells.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Multifaceted roles of mitochondria in wound healing and chronic wound pathogenesis.Frontiers in cell and developmental biology · 2023Review
- Engineering Endosymbiotic Growth ofACS synthetic biology · 2022Article
- Mitochondria transplantation between living cells.PLoS biology · 2022Article
- Microfluidic mechanoporation for cellular delivery and analysis.Materials today. Bio · 2022Review
- Microfluidic Based Physical Approaches towards Single-Cell Intracellular Delivery and Analysis.Micromachines · 2021Review
- A Microfluidic Device for Modulation of Organellar Heterogeneity in Live Single Cells.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021Article
- Photothermal Intracellular Delivery Using Gold Nanodisk Arrays.ACS materials letters · 2020Article
- Differential detachment of intact and viable cells of different sizes using laser-induced microbubbles.Biomedical optics express · 2019Article
- Current Trends of Microfluidic Single-Cell Technologies.International journal of molecular sciences · 2018Review
- Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts.Chemical reviews · 2018Review
- Enhanced intracellular delivery via coordinated acoustically driven shear mechanoporation and electrophoretic insertion.Scientific reports · 2018Article
- Plasmonic micropillars for precision cell force measurement across a large field-of-view.Applied physics letters · 2018Article
- Selective Photomechanical Detachment and Retrieval of Divided Sister Cells from Enclosed Microfluidics for Downstream Analyses.ACS nano · 2017Article
- Inner Workings: Light-controlled cellular surgery.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells.Cell metabolism · 2016Article
- Modifying the Mitochondrial Genome.Cell metabolism · 2016Review
- Supramolecular nanosubstrate-mediated delivery for reprogramming and transdifferentiation of mammalian cells.Small (Weinheim an der Bergstrasse, Germany) · 2015Article
- Massively parallel delivery of large cargo into mammalian cells with light pulses.Nature methods · 2015Article
- Nanoplasmon-enabled macroscopic thermal management.Scientific reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
It is difficult to achieve controlled cutting of elastic, mechanically fragile, and rapidly resealing mammalian cell membranes. Here, we report a photothermal nanoblade that utilizes a metallic nanostructure to harvest short laser pulse energy and convert it into a highly localized explosive vapor bubble, which rapidly punctures a lightly contacting cell membrane via high-speed fluidic flows and induced transient shear stress. The cavitation bubble pattern is controlled by the metallic structure configuration and laser pulse duration and energy. Integration of the metallic nanostructure with a micropipet, the nanoblade generates a micrometer-sized membrane access port for delivering highly concentrated cargo (5 × 10(8) live bacteria/mL) with high efficiency (46%) and cell viability (>90%) into mammalian cells. Additional biologic and inanimate cargo over 3-orders of magnitude in size including DNA, RNA, 200 nm polystyrene beads, to 2 μm bacteria have also been delivered into multiple mammalian cell types. Overall, the photothermal nanoblade is a new approach for delivering difficult cargo into mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.