ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2011
Ephrin reverse signaling controls palate fusion via a PI3 kinase-dependent mechanism.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Cellular and developmental basis of orofacial clefts.Birth defects research · 2020Review
- Article
- Closing the Gap: Mouse Models to Study Adhesion in Secondary Palatogenesis.Journal of dental research · 2017Review
- Computational Model of Secondary Palate Fusion and Disruption.Chemical research in toxicology · 2017Article
- Bidirectional ephrin signaling in bone.Osteoporosis and sarcopenia · 2016Review
- Ephrin reverse signaling mediates palatal fusion and epithelial-to-mesenchymal transition independently of Tgfß3.Journal of cellular physiology · 2015Article
- Method of Studying Palatal Fusion using Static Organ Culture.Journal of visualized experiments : JoVE · 2015Article
- IRF6 is the mediator of TGFβ3 during regulation of the epithelial mesenchymal transition and palatal fusion.Scientific reports · 2015Article
- Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Ephrin-B2 expression in the proprioceptive sensory system.Neuroscience letters · 2013Article
- Mechanisms of tissue fusion during development.Development (Cambridge, England) · 2012Review
- Ephrin regulation of synapse formation, function and plasticity.Molecular and cellular neurosciences · 2012Review
- Non-SH2/PDZ reverse signaling by ephrins.Seminars in cell & developmental biology · 2012Review
- Ephrin regulation of palate development.Frontiers in physiology · 2012Article
- Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues.Developmental biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Secondary palate fusion requires adhesion and epithelial-to-mesenchymal transition (EMT) of the epithelial layers on opposing palatal shelves. This EMT requires transforming growth factor β3 (TGFβ3), and its failure results in cleft palate. Ephrins, and their receptors, the Ephs, are responsible for migration, adhesion, and midline closure events throughout development. Ephrins can also act as signal-transducing receptors in these processes, with the Ephs serving as ligands (termed "reverse" signaling). We found that activation of ephrin reverse signaling in chicken palates induced fusion in the absence of TGFβ3, and that PI3K inhibition abrogated this effect. Further, blockage of reverse signaling inhibited TGFβ3-induced fusion in the chicken and natural fusion in the mouse. Thus, ephrin reverse signaling is necessary and sufficient to induce palate fusion independent of TGFβ3. These data describe both a novel role for ephrins in palate morphogenesis, and a previously unknown mechanism of ephrin signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.