ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2011
GABAergic and glutamatergic identities of developing midbrain Pitx2 neurons.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells.Neural development · 2023Article
- Comprehensive spatiotemporal mapping of single-cell lineages in developing mouse brain by CRISPR-based barcoding.Nature methods · 2023Article
- Dorsoventral Arrangement of Lateral Hypothalamus Populations in the Mouse Hypothalamus: a Prosomeric Genoarchitectonic Analysis.Molecular neurobiology · 2023Article
- Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson's disease model.The Journal of clinical investigation · 2022Article
- The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain.eLife · 2021Article
- Dynamic neurotransmitter specific transcription factor expression profiles duringBiology open · 2020Article
- Pitx2 cholinergic interneurons are the source of C bouton synapses on brainstem motor neurons.Scientific reports · 2019Article
- Sequential Role of SOXB2 Factors in GABAergic Neuron Specification of the Dorsal Midbrain.Frontiers in molecular neuroscience · 2018Article
- Deficiency of the Thyroid Hormone Transporter Monocarboxylate Transporter 8 in Neural Progenitors Impairs Cellular Processes Crucial for Early Corticogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Odorant Sensory Input Modulates DNA Secondary Structure Formation and Heterogeneous Ribonucleoprotein Recruitment on the Tyrosine Hydroxylase and Glutamic Acid Decarboxylase 1 Promoters in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Mechanisms regulating GABAergic neuron development.Cellular and molecular life sciences : CMLS · 2014Review
- C-terminals in the mouse branchiomotor nuclei originate from the magnocellular reticular formation.Neuroscience letters · 2013Article
- Comparative genomics using teleost fish helps to systematically identify target gene bodies of functionally defined human enhancers.BMC genomics · 2013Article
- The LIM homeodomain transcription factor LHX6: a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulate odontogenesis.The Journal of biological chemistry · 2013Article
- Microarray analysis of perinatal-estrogen-induced changes in gene expression related to brain sexual differentiation in mice.PloS one · 2013Article
- Pleiotropic and isoform-specific functions for Pitx2 in superior colliculus and hypothalamic neuronal development.Molecular and cellular neurosciences · 2013Article
- The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation.Neural development · 2012Article
- Distinct populations of GABAergic neurons in mouse rhombomere 1 express but do not require the homeodomain transcription factor PITX2.Molecular and cellular neurosciences · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Pitx2, a paired-like homeodomain transcription factor, is expressed in post-mitotic neurons within highly restricted domains of the embryonic mouse brain. Previous reports identified critical roles for PITX2 in histogenesis of the hypothalamus and midbrain, but the cellular identities of PITX2-positive neurons in these regions were not fully explored. This study characterizes Pitx2 expression with respect to midbrain transcription factor and neurotransmitter phenotypes in mid-to-late mouse gestation. In the dorsal midbrain, we identified Pitx2-positive neurons in the stratum griseum intermedium (SGI) as GABAergic and observed a requirement for PITX2 in GABAergic differentiation. We also identified two Pitx2-positive neuronal populations in the ventral midbrain, the red nucleus, and a ventromedial population, both of which contain glutamatergic precursors. Our data suggest that PITX2 is present in regionally restricted subpopulations of midbrain neurons and may have unique functions that promote GABAergic and glutamatergic differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.