ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2011
Noncanonical Notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of Trio.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- The Abelson kinase and the Nedd4 family E3 ligases co-regulate Notch trafficking to limit signaling.The Journal of cell biology · 2025Article
- The RNA-binding protein Nab2 regulates levels of the RhoGEF Trio to govern axon and dendrite morphology.Molecular biology of the cell · 2024Article
- Pathogenic TRIO variants associated with neurodevelopmental disorders perturb the molecular regulation of TRIO and axon pathfinding in vivo.Molecular psychiatry · 2023Article
- p53 regulates the effects of DAPT on Rac1 activation and migration of non-small-cell lung cancer cells.Heliyon · 2023Article
- Notch-dependent Abl signaling regulates cell motility during ommatidial rotation in Drosophila.Cell reports · 2022Article
- Review
- Non-canonical Notch Signaling Regulates Actin Remodeling in Cell Migration by Activating PI3K/AKT/Cdc42 Pathway.Frontiers in pharmacology · 2019Article
- Review
- Actin-based growth cone motility and guidance.Molecular and cellular neurosciences · 2017Review
- Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration.The Journal of cell biology · 2017Article
- The Abl pathway bifurcates to balance Enabled and Rac signaling in axon patterning in Drosophila.Development (Cambridge, England) · 2017Article
- Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease.Acta neuropathologica communications · 2016Article
- Mechanism of Notch Pathway Activation and Its Role in the Regulation of Olfactory Plasticity in Drosophila melanogaster.PloS one · 2016Article
- Notch is required in adult Drosophila sensory neurons for morphological and functional plasticity of the olfactory circuit.PLoS genetics · 2015Article
- Targeting the Notch signaling pathway in cancer therapeutics.Thoracic cancer · 2014Review
- The Abl/enabled signaling pathway regulates Golgi architecture in Drosophila photoreceptor neurons.Molecular biology of the cell · 2014Article
- Invasive cells in animals and plants: searching for LECA machineries in later eukaryotic life.Biology direct · 2013Review
- Article
- Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases.Frontiers in synaptic neuroscience · 2013Article
- Kalrn plays key roles within and outside of the nervous system.BMC neuroscience · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The receptor Notch interacts with the Abl tyrosine kinase signaling pathway to control axon growth and guidance in Drosophila motor neurons. In part, this is mediated by binding to Trio, a guanine nucleotide exchange factor (GEF) for Rho GTPases. We show here that one of the two GEF domains of Trio, the Rac-specific GEF1, is essential for Trio-dependent motor axon guidance and for the genetic suppression of Notch function in motor axon patterning, but the Rho-specific GEF2 domain is not. Consistent with this, we show that Rac, and not Rho1 or Cdc42, interacts genetically with Notch in a manner indistinguishable from that of bona fide Abl signaling components. We infer, therefore, that Rac is a key component of Abl signaling in Drosophila motor axons, and specifically that it is the crucial Rho GTPase in "noncanonical" Notch/Abl signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.