ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2011
Epibranchial placode-derived neurons produce BDNF required for early sensory neuron development.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Embryonic mesenchyme, mesenchymal tumors and mesenchymal stem cells: need for clarification of cell types and standardization of biomedical terminology.Cellular and molecular life sciences : CMLS · 2025Review
- From neural crest migration to the onset of gangliogenesis.Current topics in developmental biology · 2025Review
- Exosome-shuttled miR-126 mediates ethanol-induced disruption of neural crest cell-placode cell interaction by targeting SDF1.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Intra-amniotic transplantation of brain-derived neurotrophic factor-modified mesenchymal stem cells treatment for rat fetuses with spina bifida aperta.Stem cell research & therapy · 2022Article
- Elp1 is required for development of visceral sensory peripheral and central circuitry.Disease models & mechanisms · 2022Article
- BDNF and NGF signals originating from sensory ganglia promote cranial motor axon growth.Experimental brain research · 2020Article
- The transcription factor Phox2b distinguishes between oral and non-oral sensory neurons in the geniculate ganglion.The Journal of comparative neurology · 2017Article
- BDNF is required for taste axon regeneration following unilateral chorda tympani nerve section.Experimental neurology · 2017Article
- Insulin-Like Growth Factors Are Expressed in the Taste System, but Do Not Maintain Adult Taste Buds.PloS one · 2016Article
- Neural crest and placode interaction during the development of the cranial sensory system.Developmental biology · 2014Review
- BDNF and NT4 play interchangeable roles in gustatory development.Developmental biology · 2014Article
- A fate-map for cranial sensory ganglia in the sea lamprey.Developmental biology · 2014Article
- Cranial neural crest cells form corridors prefiguring sensory neuroblast migration.Development (Cambridge, England) · 2013Article
- Taste neurons consist of both a large TrkB-receptor-dependent and a small TrkB-receptor-independent subpopulation.PloS one · 2013Article
- Neurotrophin-4 regulates the survival of gustatory neurons earlier in development using a different mechanism than brain-derived neurotrophic factor.Developmental biology · 2012Article
- Hmx1 is required for the normal development of somatosensory neurons in the geniculate ganglion.Developmental biology · 2012Article
- Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
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4 authors at 2 institutions in 1 country.
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Abstract
In mice, BDNF provided by the developing taste epithelium is required for gustatory neuron survival following target innervation. However, we find that expression of BDNF, as detected by BDNF-driven β-galactosidase, begins in the cranial ganglia before its expression in the central (hindbrain) or peripheral (taste papillae) targets of these sensory neurons, and before gustatory ganglion cells innervate either target. To test early BDNF function, we examined the ganglia of bdnf null mice before target innervation, and found that while initial neuron survival is unaltered, early neuron development is disrupted. In addition, fate mapping analysis in mice demonstrates that murine cranial ganglia arise from two embryonic populations, i.e., epibranchial placodes and neural crest, as has been described for these ganglia in non-mammalian vertebrates. Only placodal neurons produce BDNF, however, which indicates that prior to innervation, early ganglionic BDNF produced by placode-derived cells promotes gustatory neuron development.
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