ArticleBiotechnology and bioengineering2011
Characterization of combinatorial patterns generated by multiple two-component sensors in E. coli that respond to many stimuli.
Article in Biotechnology and bioengineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The divergentMicrobiology (Reading, England) · 2026Article
- Bacterial cell widening alters periplasmic size and activates envelope stress responses.The EMBO journal · 2025Article
- Design of a water-soluble transmembrane receptor kinase with intact molecular function by QTY code.Nature communications · 2024Article
- Real-time detection of response regulator phosphorylation dynamics in live bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Contribution of the Locus of Heat Resistance to Growth and Survival ofMicroorganisms · 2021Article
- Transcriptomic analysis reveals the role of RcsB in suppressing bacterial chemotaxis, flagellar assembly and infection in Yersinia enterocolitica.Current genetics · 2020Article
- How bacteria recognise and respond to surface contact.FEMS microbiology reviews · 2020Review
- Osmoregulated Periplasmic Glucans Transmit External Signals Through Rcs Phosphorelay Pathway inFrontiers in microbiology · 2020Article
- Nutrient depletion may trigger the Yersinia pestis OmpR-EnvZ regulatory system to promote flea-borne plague transmission.Molecular microbiology · 2019Article
- Reassessing the role of the Escherichia coli CpxAR system in sensing surface contact.PloS one · 2018Article
- The opgC gene is required for OPGs succinylation and is osmoregulated through RcsCDB and EnvZ/OmpR in the phytopathogen Dickeya dadantii.Scientific reports · 2016Article
- Mutations That Enhance the Ciprofloxacin Resistance of Escherichia coli with qnrA1.Antimicrobial agents and chemotherapy · 2015Article
- New insights into the biological role of the osmoregulated periplasmic glucans in pathogenic and symbiotic bacteria.Environmental microbiology reports · 2015Review
- Synthetic microbes as drug delivery systems.ACS synthetic biology · 2015Review
- Article
- Permanent genetic memory with >1-byte capacity.Nature methods · 2014Article
- Alkali metals in addition to acidic pH activate the EvgS histidine kinase sensor in Escherichia coli.Journal of bacteriology · 2014Article
- Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation.PLoS biology · 2014Article
- Eliminating a set of four penicillin binding proteins triggers the Rcs phosphorelay and Cpx stress responses in Escherichia coli.Journal of bacteriology · 2013Article
- Foundations for the design and implementation of synthetic genetic circuits.Nature reviews. Genetics · 2012Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Two-component systems enable bacteria to sense changes in their environment and adjust gene expression in response. Multiple two-component systems could function as a combinatorial sensor to discriminate environmental conditions. A combinatorial sensor is composed of a set of sensors that are non-specifically activated to different magnitudes by many stimuli, such that their collective activity pattern defines the signal. Using promoter reporters and flow cytometry, we measured the response of three two-component systems in Escherichia coli that have been previously reported to respond to many environmental stimuli (EnvZ/OmpR, CpxA/CpxR, and RcsC/RcsD/RcsB). A chemical library was screened for the ability to activate the sensors and 13 inducers were identified that produce different patterns of sensor activity. The activities of the three systems are uncorrelated with each other and the osmolarity of the inducing media. Five of the seven possible non-trivial patterns generated by three sensors are observed. This data demonstrate one mechanism by which bacteria are able to use a limited set of sensors to identify a diverse set of compounds and environmental conditions.
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