ArticleRheumatology international2012
The status of serum vitamin D in patients with rheumatoid arthritis and undifferentiated inflammatory arthritis compared with controls.
Article in Rheumatology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Pooled it
- The association between vitamin D concentration and pain: a systematic review and meta-analysis.Public health nutrition · 2018Pooled it
- Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis.PloS one · 2016Pooled it
- Trial
- Observational
- Development and evaluation of methods of clinical utility-based cut-point selection of diagnostic biomarkers: an analysis based on population-level parametric distributions of test results with application of clinical diagnostic data.BMC medical research methodology · 2025Article
- Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response.BioMed research international · 2019Review
- The effect of vitamin D on clinical manifestations and activity of Behçet's disease.Postepy dermatologii i alergologii · 2017Article
- Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: "The COMORA Study".International journal of rheumatology · 2017Article
- Determinants of pain in patients with symptomatic knee osteoarthritis.Caspian journal of internal medicine · 2016Review
- Vitamin D status of patients with early inflammatory arthritis.Clinical rheumatology · 2015Article
- Vitamin D status and distribution in patients with chronic obstructive pulmonary disease versus healthy controls.Caspian journal of internal medicine · 2015Article
- Vitamin D deficiency leads to sensory and sympathetic denervation of the rat synovium.Neuroscience · 2014Article
- Vitamin D deficiency in patients with Behcet's disease.Journal of diabetes and metabolic disorders · 2014Article
- 25(OH) vitamin D serum values and rheumatoid arthritis disease activity (DA S28 ESR).Caspian journal of internal medicine · 2014Article
- Relationship between serum vitamin D and forced expiratory volume in patients with chronic obstructive pulmonary disease (COPD).Caspian journal of internal medicine · 2012Article
- Seasonal variations in serum vitamin D according to age and sex.Caspian journal of internal medicine · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inadequate vitamin D may be involved in the pathogenesis and or progression of several disorders, including connective tissue diseases. To determine the status of vitamin D in different stages of inflammatory arthritis, the levels of vitamin D in established rheumatoid arthritis (RA) and undifferentiated inflammatory arthritis (UIA) were compared with controls. Patients with RA and UIA entered the study. Serum 25-hydroxyvitamin D (25-OHD) was measured by ELISA method, and concentrations less than 20 ng/ml were considered as deficient levels. In statistical analysis, the Mann-Whitney U test was used for comparing differences between groups and logistic regression analysis with calculation of adjusted odds ratio (OR) was used to determine the association between serum 25-OHD deficiency and disease condition. A total of 108 RA, 39 UIA, and 239 controls were studied. There were no significant differences in mean serum 25-OHD level and frequency of serum 25-OHD deficiency between RA and controls (37 ± 37.7 vs. 33.2 ± 28.6 ng/ml, P = 0.96). But the mean serum 25-OHD level in UIA was significantly lower than in the controls (25.1 ± 23.9 vs. 33.2 ± 28.6 ng ml, P = 0.04). A significant positive association was observed between serum 25-OHD deficiency and UIA (56.4% vs. 35.5%, OR = 2.34, 95% CI, 1.18-4.65, P = 0.021) which remained significant after adjustment for sex and age (adjusted OR = 2.24, 95% CI, 1.01-4.55, P = 0.026). Whereas the association between serum 25-OHD deficiency and RA did not reach statistical significance (40.7% vs. 35.5%, OR = 1.24, 95% CI, 0.78-1.99). These findings indicate higher serum vitamin D deficiency in patients with ongoing arthritis rather than established arthritis. Respecting to deleterious effects of vitamin D deficiency on immune system and progressive nature of UIA, a significant proportion of high risk UIA can be recognized by serum 25-OHD determination.
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