ArticleEuropean journal of clinical pharmacology2011
Adverse drug events in an intensive care unit of a university hospital.
Article in European journal of clinical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence of drug interactions in hospitalised elderly patients: a systematic review.European journal of hospital pharmacy : science and practice · 2021Pooled it
- Evaluation of Potential Drug-Drug Interactions in Adults in the Intensive Care Unit: A Systematic Review and Meta-Analysis.Drug safety · 2019Pooled it
- Trial
- Assessment of Knowledge and Attitudes Toward Potential Drug-Drug and Drug-Food Interactions and Associated Factors Among Health Care Professionals at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia: A Cross-Sectional Study.Health science reports · 2026Article
- Potential drug-drug interactions among hospitalised cardiac patients in Nepal: a prospective observational study.BMJ open · 2025Observational
- Prevalence and clinical significance of potential drug-drug interactions of antimicrobials in Intensive Care Unit patients: a retrospective study.BMC pharmacology & toxicology · 2025Article
- Evaluation of Potential Drug-Drug Interactions Caused by Antibacterial and Antifungal Drugs in the Intensive Care Unit: A Retrospective Cross-Sectional Study.Journal of clinical practice and research · 2023Article
- Frequency, Predictors, and Outcomes of the Potential Drug-Drug Interactions in the ICUs of Teaching Hospitals in Ardabil, Northwest of Iran During 2019-2020.Hospital pharmacy · 2023Article
- Natural products for the prevention of antibiotic-associated kidney injury.Current opinion in toxicology · 2022Article
- Prevalence of potential drug - drug interactions in the cardiothoracic intensive care unit patients in a Chinese tertiary care teaching hospital.BMC pharmacology & toxicology · 2022Article
- Clinical pharmacist assessment of drug-related problems among intensive care unit patients in a Turkish university hospital.BMC health services research · 2022Article
- A Clinician's Guide to Dosing Analgesics, Anticonvulsants, and Psychotropic Medications in Continuous Renal Replacement Therapy.Kidney international reports · 2021Review
- [Pharmacological/pharmaceutical counseling in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2021Article
- Clinical significance of potential drug-drug interactions in a pediatric intensive care unit: A single-center retrospective study.PloS one · 2021Article
- Molecular Mechanisms of AKI in the Elderly: From Animal Models to Therapeutic Intervention.Journal of clinical medicine · 2020Review
- Identifying and Characterizing Serious Adverse Drug Reactions Associated With Drug-Drug Interactions in a Spontaneous Reporting Database.Frontiers in pharmacology · 2020Article
- Medication errors and drug knowledge gaps among critical-care nurses: a mixed multi-method study.BMC health services research · 2019Article
- The effect of ICU-tailored drug-drug interaction alerts on medication prescribing and monitoring: protocol for a cluster randomized stepped-wedge trial.BMC medical informatics and decision making · 2019Article
- Impact of medication therapy management on pharmacotherapy safety in an intensive care unit.International journal of clinical pharmacy · 2019Article
- Trigger tools are as effective as non-targeted chart review for adverse drug event detection in intensive care units.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdverse drug events (ADEs) are harmful and occur with alarming frequency in critically ill patients. Complex pharmacotherapy with multiple medications increases the probability of a drug interaction (DI) and ADEs in patients in intensive care units (ICUs). The objective of the study is to determine the frequency of ADEs among patients in the ICU of a university hospital and the drugs implicated. Also, factors associated with ADEs are investigated.
methodsThis cross-sectional study investigated 299 medical records of patients hospitalized for 5 or more days in an ICU. ADEs were identified through intensive monitoring adopted in hospital pharmacovigilance and also ADE triggers. Adverse drug reactions (ADR) causality was classified using the Naranjo algorithm. Data were analyzed through descriptive analysis, and through univariate and multiple logistic regression.
resultsThe most frequent ADEs were ADRs type A, of possible causality and moderate severity. The most frequent ADR was drug-induced acute kidney injury. Patients with ADEs related to DIs corresponded to 7% of the sample. The multiple logistic regression showed that length of hospitalization (OR = 1.06) and administration of cardiovascular drugs (OR = 2.2) were associated with the occurrence of ADEs.
conclusionAdverse drug reactions of clinical significance were the most frequent ADEs in the ICU studied, which reduces patient safety. The number of ADEs related to drug interactions was small, suggesting that clinical manifestations of drug interactions that harm patients are not frequent in ICUs.
Indexed as
Identifiers
21246350What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.