ArticleMolecular imaging and biology2011
Labeling of Luciferase/eGFP-expressing bone marrow-derived stromal cells with fluorescent micron-sized iron oxide particles improves quantitative and qualitative multimodal imaging of cellular grafts in vivo.
Article in Molecular imaging and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment.Scientific reports · 2021Article
- Review
- Continual conscious bioluminescent imaging in freely moving somatotransgenic mice.Scientific reports · 2017Article
- Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations.International journal of nanomedicine · 2017Review
- Article
- Tackling the physiological barriers for successful mesenchymal stem cell transplantation into the central nervous system.Stem cell research & therapy · 2013Review
- Article
- Spatiotemporal evolution of early innate immune responses triggered by neural stem cell grafting.Stem cell research & therapy · 2012Article
- Multimodal imaging of stem cell implantation in the central nervous system of mice.Journal of visualized experiments : JoVE · 2012Article
- Meeting report of the first conference of the International Placenta Stem Cell Society (IPLASS).Placenta · 2011Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDevelopment of multimodal imaging strategies is currently of utmost importance for the validation of preclinical stem cell therapy studies. PROCEDURES: We performed a combined labeling strategy for bone marrow-derived stromal cells (BMSC) based on genetic modification with the reporter genes Luciferase and eGFP (BMSC-Luc/eGFP) and physical labeling with blue fluorescent micron-sized iron oxide particles (MPIO) in order to unambiguously identify BMSC localization, survival, and differentiation following engraftment in the central nervous system of mice by in vivo bioluminescence (BLI) and magnetic resonance imaging and postmortem histological analysis.
resultsUsing this combination, a significant increase of in vivo BLI signal was observed for MPIO-labeled BMSC-Luc/eGFP. Moreover, MPIO labeling of BMSC-Luc/eGFP allows for the improved identification of implanted cells within host tissue during histological observation.
conclusionsThis study describes an optimized labeling strategy for multimodal stem cell imaging resulting in improved quantitative and qualitative detection of cellular grafts.
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