ArticleJournal of fluorescence2011
Ultrasensitive study of gatifloxacin based on its enhancing effect on the cerium (IV)-sodium hyposulfite chemiluminescence reaction in a micellar medium.
Article in Journal of fluorescence, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- CL sensitisation of tris-(bipyridyl) ruthenium (II) - cerium (IV) reaction system by AgNPs for determination of GFX.IET nanobiotechnology · 2018Article
- Energy transfer processes of chemiluminescence reaction systems with cerium(IV) ions and their analytical application: a review.Journal of fluorescence · 2015Article
- Investigation on the micelle-sensitized Ce(IV)-lornoxicam-Rh B chemiluminescence system and its application.Journal of fluorescence · 2012Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A sensitive and rapid flow-injection chemiluminescence (CL) method has been developed for the determination of gatifloxacin in pharmaceutical preparations and biological samples. The method is based on the enhancing effect of gatifloxacin on CL emission generated by the interaction of Ce (IV) in sulphuric acid and sodium hyposulphite (Na(2)S(2)O(4)) sensitized by sodium dodecyl benzene sulfonate (SDBS). Strong CL emission was observed when gatifloxacin was injected into the Ce (IV) in sulphuric acid and Na(2)S(2)O(4) solution incorporated with SDBS in a flow-cell. Several experimental parameters affecting the CL reaction were investigated and optimized systematically. Under the optimum conditions, it was found that the CL intensity is proportional to the concentration of gatifloxacin in the range of 1.12 × 10(-11)-4.40 × 10(-9) g mL(-1) with a co-relation coefficient of 0.9994. The limit of detection was found to be 4.87 × 10(-12) g mL(-1) and the relative standard deviation (RSD, n=7) was 1.8% for 4 × 10(-8) g mL(-1) of GFLX. The proposed method offers higher sensitivity, wide linear range and better stability without requiring sophisticated instrumentation. Thus, the proposed method has been successfully applied to the determination of gatifloxacin in pharmaceuticals, serum and human urine.
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