ArticleMolecular and cellular biochemistry2011
Malignant transformation of 293 cells induced by ectopic expression of human Nanog.
Article in Molecular and cellular biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Identification of Nanog as a novel inhibitor of Rad51.Cell death & disease · 2022Article
- The IGF2/IGF1R/Nanog Signaling Pathway Regulates the Proliferation of Acute Myeloid Leukemia Stem Cells.Frontiers in pharmacology · 2018Article
- siRNA-mediated knockdown of ID1 disrupts Nanog- and Oct-4-mediated cancer stem cell-likeness and resistance to chemotherapy in gastric cancer cells.Oncology letters · 2017Article
- Reprogramming Malignant Cancer Cells toward a Benign Phenotype following Exposure to Human Embryonic Stem Cell Microenvironment.PloS one · 2017Article
- NANOG as an adverse predictive marker in advanced non-small cell lung cancer treated with platinum-based chemotherapy.OncoTargets and therapy · 2017Article
- Pluripotency factor Nanog is tumorigenic by deregulating DNA damage response in somatic cells.Oncogene · 2016Article
- Concise Review: NANOG in Cancer Stem Cells and Tumor Development: An Update and Outstanding Questions.Stem cells (Dayton, Ohio) · 2015Review
- A three-gene signature and clinical outcome in esophageal squamous cell carcinoma.International journal of cancer · 2015Article
- Transfer of malignant trait to immortalized human cells following exposure to human cancer serum.Journal of experimental & clinical cancer research : CR · 2014Article
- Article
- Targeting FAK in human cancer: from finding to first clinical trials.Frontiers in bioscience (Landmark edition) · 2014Review
- Targeting cancer stem cells: emerging role of Nanog transcription factor.OncoTargets and therapy · 2013Review
- Autochthonous mouse melanoma and mammary tumors do not express the pluripotency genes Oct4 and Nanog.PloS one · 2013Article
- Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated.The Journal of biological chemistry · 2012Article
- Immortalized cells and one oncogene in malignant transformation: old insights on new explanation.BMC cell biology · 2011Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor development has long been known to resemble abnormal embryogenesis. The ESC self-renewal gene NANOG is purportedly expressed in some epithelial cancer cells and solid tumors, but a casual role in tumor development has remained unclear. In order to more comprehensively elucidate the relationship between human Nanog and tumorigenesis, the hNanog was ectopically expressed in the 293 cell line to investigate its potential for malignant transformation of cells both in vitro and in vivo. Here we provide compelling evidence that the overexpression of hNanog resulted in increased cell proliferation, anchor-independent growth in soft agar, and formation of tumors after subcutaneous injection of athymic nude mice. Pathologic analysis revealed that these tumors were poorly differentiated. In analysis of the underlying molecular mechanism, two proteins, FAK and Ezrin, were identified to be upregulated in the hNanog expressing 293 cells. Our results demonstrate that hNanog is a potent human oncogene and has the ability to induce cellular transformation of human cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.