ArticlePlant molecular biology2011
Overproduction of a rice aldo-keto reductase increases oxidative and heat stress tolerance by malondialdehyde and methylglyoxal detoxification.
Article in Plant molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 157 citations in OpenAlex.
- Design Principles of Plant Thermotolerance: Integrating Photosynthesis, Reproduction, and Field Resilience in a Warming Climate.Plant, cell & environment · 2026Review
- Multi-level responses of Camellia reticulata to heat stress: insights from photosynthetic performance, antioxidant activity, lipidomics, and fatty acid profiling.BMC plant biology · 2026Article
- Identification of candidate genes for heat tolerance in rice by genome-wide association study and transcriptome sequencing.BMC plant biology · 2026Article
- Phenotypic and biochemical responses of high-yield tomato varieties to salinity and drought stress.PloS one · 2026Article
- Genome-wide identification analysis of aldo-keto reductase gene family in cotton and GhAKR40 role in salt stress tolerance.Functional & integrative genomics · 2025Article
- Isolation, identification, and pathogenicity ofMicrobiology spectrum · 2025Article
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- Genome-wide identification of NDR1/HIN1-like genes in kiwifruit and function analysis of AeNHL17 in response to disease resistance.BMC plant biology · 2024Article
- Genome-wide association study reveals effect of nsSNPs on candidate genes in rice during iron deficiency.Functional & integrative genomics · 2024Article
- Promoter of COR2-like gene is a stress inducible regulatory region in banana.Transgenic research · 2024Article
- Comparison of Glyphosate-Degradation Ability of Aldo-Keto Reductase (AKR4) Proteins in Maize, Soybean and Rice.International journal of molecular sciences · 2023Article
- Genome-Wide Identification and Characterization ofInternational journal of molecular sciences · 2023Article
- Pyramiding of transcription factor,Frontiers in plant science · 2023Article
- Involvement of osmoregulation, glyoxalase, and non-glyoxalase systems in signaling molecule glutamic acid-boosted thermotolerance in maize seedlings.Protoplasma · 2022Article
- Review
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- Degradome sequencing reveals an integrative miRNA-mediated gene interaction network regulating rice seed vigor.BMC plant biology · 2022Article
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- Growth, Yield, and Bunch Quality of "Superior Seedless" Vines Grown on Different Rootstocks Change in Response to Salt Stress.Plants (Basel, Switzerland) · 2021Article
- Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The accumulation of toxic compounds generated by the interaction between reactive oxygen species and polyunsaturated fatty acids of membrane lipids can significantly damage plant cells. A plethora of enzymes act on these reactive carbonyls, reducing their toxicity. Based on the chromosomal localization and on their homology with other stress-induced aldo-keto reductases (AKRs) we have selected three rice AKR genes. The transcription level of OsAKR1 was greatly induced by abscisic acid and various stress treatments; the other two AKR genes tested were moderately stress-inducible. The OsAKR1 recombinant protein exhibited a high nicotinamide adenine dinucleotide phosphate-dependent catalytic activity to reduce toxic aldehydes including glycolysis-derived methylglyoxal (MG) and lipid peroxidation-originated malondialdehyde (MDA). The function of this enzyme in MG detoxification was demonstrated in vivo in E. coli and in transgenic plants overproducing the OsAKR1 protein. Heterologous synthesis of the OsAKR1 enzyme in transgenic tobacco plants resulted in increased tolerance against oxidative stress generated by methylviologen (MV) and improved resistance to high temperature. In these plants lower levels of MDA were detected both following MV and heat treatment due to the activity of the OsAKR1 enzyme. The transgenic tobaccos also exhibited higher AKR activity and accumulated less MG in their leaves than the wild type plants; both in the presence and absence of heat stress. These results support the positive role of OsAKR1 in abiotic stress-related reactive aldehyde detoxification pathways and its use for improvement of stress tolerance in plants.
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