ArticleEuropean radiology2011
Protocol modifications for CT perfusion (CTp) examinations of abdomen-pelvic tumors: impact on radiation dose and data processing time.
Article in European radiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 29 citations in OpenAlex.
- Effect on perfusion values of sampling interval of computed tomographic perfusion acquisitions in neuroendocrine liver metastases and normal liver.Journal of computer assisted tomographyTrial
- Quantitative evaluation of pancreatic neuroendocrine tumors utilizing dual-source CT perfusion imaging.BMC medical imaging · 2024Article
- Effect of scan duration on CT perfusion values in metastases from renal cell carcinoma.Research in diagnostic and interventional imaging · 2023Article
- CT liver perfusion in patients with hepatocellular carcinoma: can we modify acquisition protocol to reduce patient exposure?European radiology · 2021Article
- Intra- and interobserver reproducibility of pancreatic perfusion by computed tomography.Scientific reports · 2019Article
- Variability and Reproducibility of 3Scientific reports · 2018Article
- Inferring Stable Acquisition Durations for Applications of Perfusion Imaging in Oncology.Cancer informatics · 2015Article
- A Bayesian Nonparametric Approach for Functional Data Classification with Application to Hepatic Tissue Characterization.Cancer informatics · 2015Article
- Computed tomography perfusion imaging as a potential imaging biomarker of colorectal cancer.World journal of gastroenterology · 2014Review
- Study of 320-slice dynamic volume CT perfusion in different pathologic types of kidney tumor: preliminary results.PloS one · 2014Article
- Metastases to the liver from neuroendocrine tumors: effect of duration of scan acquisition on CT perfusion values.Radiology · 2013Article
- Effect of sampling frequency on perfusion values in perfusion CT of lung tumors.AJR. American journal of roentgenology · 2013Article
- Pancreatic Perfusion CT in Early Stage of Severe Acute Pancreatitis.International journal of inflammation · 2012Article
- Reproducibility and variability of very low dose hepatic perfusion CT in metastatic liver disease.Diagnostic and interventional radiology (Ankara, Turkey)Article
- Effect of pre-enhancement set point on computed tomographic perfusion values in normal liver and metastases to the liver from neuroendocrine tumors.Journal of computer assisted tomographyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the effect of CT perfusion (CTp) protocol modifications on quantitative perfusion parameters, radiation dose and data processing time. MATERIALS &
methodsCTp datasets of 30 patients (21M:9F) with rectal (n = 24) or retroperitoneal (n = 6) tumours were studied. Standard CTp protocol included 50 sec cine-phase (0.5 sec/rotation) and delayed-phase after 70 ml contrast bolus at 5-7 ml/sec. CTp-data was sub-sampled to generate modified datasets (n = 105) with cine-phase(n = 15) alone, varying cine-phase duration (20-40 sec, n = 45) and varying temporal sampling-interval (1-3 sec, n = 45). The estimated CTp parameters (BF,BV,MTT&PS) and radiation dose of standard CTp served as reference for comparison.
resultsCTp with 50 sec cine-phase showed moderate to high correlation with standard CTp for BF&MTT (r = 0.96&0.85) and low correlation for BV (0.75, p = 0.04). Limiting cine-phase duration to 30 sec demonstrated comparable results for BF&MTT, while considerable variation in CTp values existed at 20 sec. There was moderate-to-high correlation of CTp parameters with sampling interval of 1&2 sec (r = 0.83-0.97, p > 0.05), while at 3 sec only BF showed high correlation (r = 0.96, p = 0.05). Increasing sampling interval (47-60%) and reducing cine-phase duration substantially reduced dose(30.8-65%) which paralleled reduced data processing time (3-10 min).
conclusionLimiting CTp cine-phase to 30 sec results in comparable BF&MTT values and increasing cine-phase sampling interval to 2 sec provides good correlation for all CTp parameters with substantial dose reduction and improved computational efficiency.
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