ReviewUrological research2011
A hypothesis of calcium stone formation: an interpretation of stone research during the past decades.
Review in Urological research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 100 citations in OpenAlex.
- Elemental composition analysis of calcium-based urinary stones via laser-induced breakdown spectroscopy for enhanced clinical insights.Scientific reports · 2025Article
- Post-ESWL urinary osteopontin level and ion-activity product of calcium oxalate are associated with stone recurrence after 5-year follow-up.BMC urology · 2025Article
- Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells.Clinical and experimental pharmacology & physiology · 2023Article
- TRPC Channels in the Physiology and Pathophysiology of the Renal Tubular System: What Do We Know?International journal of molecular sciences · 2022Review
- Hypercalciuria switches CaGenes & diseases · 2022Article
- Association of hypercalciuria with vitamin D supplementation in patients undergoing ketogenic dietary therapy.Frontiers in nutrition · 2022Article
- Differential biomolecular recognition by syntheticJournal of materials chemistry. B · 2021Article
- Trends in urinary stone composition in 23,182 stone analyses from 2011 to 2019: a high-volume center study in China.World journal of urology · 2021Article
- Modulation of Tubular pH by Acetazolamide in a CaInternational journal of molecular sciences · 2021Article
- Predicting the risk of kidney stone formation in the nephron by 'reverse engineering'.Urolithiasis · 2020Article
- Vision for the future on urolithiasis: research, management, education and training-some personal views.Urolithiasis · 2019Review
- Article
- Evidence for a regulated CaJournal of cell science · 2019Article
- Genetics of common complex kidney stone disease: insights from genome-wide association studies.Urolithiasis · 2019Review
- Melamine promotes calcium crystal formation in three-dimensional microfluidic device.Scientific reports · 2019Article
- Vitamin D and calcium kidney stones: a review and a proposal.International urology and nephrology · 2019Review
- Calcium-sensing receptor (CaSR) modulates vacuolar HClinical and experimental nephrology · 2018Article
- A Drosophila genetic model of nephrolithiasis: transcriptional changes in response to diet induced stone formation.BMC urology · 2017Article
- Article
- Novel porcine model for calcium oxalate stone formation.International urology and nephrology · 2017Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An interpretation of previous and recent observation on calcium salt crystallization and calcium stone formation provide the basis for formulation of a hypothetical series of events leading to calcium oxalate (CaOx) stone formation in the urinary tract. The various steps comprise a primary precipitation of calcium phosphate (CaP) at high nephron levels, establishment of large intratubular and/or interstitial (sub-epithelial) aggregates of CaP. These crystal masses subsequently might be dissolved during periods with low urine pH. On the denuded surface of subepithelial or intratubularly trapped CaP, release of calcium ions can result in very high ion-activity products of CaOx, particularly during simultaneous periods with peaks of CaOx supersaturation. Crystals of CaOx may result from nucleation in the macromolecular environment surrounding the apatite crystal phase. In the presence of low pH, low citrate and high ion-strength of urine, formation of large CaOx crystal masses can be accomplished by self-aggregation of Tamm-Horsfall mucoprotein. Following dislodgment of the initially fixed CaOx stone embryo, the further development into to clinically relevant stone is accomplished by CaOx crystal growth and CaOx crystal aggregation of the retained stone material. The latter process is modified by a number of inhibitors and promoters present in urine. The retention of the stone is a consequence of anatomical as well as hydrodynamic factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.