ArticlePloS one2011
Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- A systematic review and meta-analysis for the adverse effects, immunogenicity and efficacy of Lyme disease vaccines: Guiding novel vaccine development.Canadian journal of public health = Revue canadienne de sante publique · 2017Pooled it
- A lipid-binding protein in black-legged tick saliva selectively recognizesbioRxiv : the preprint server for biology · 2026Article
- Tick feeding or vaccination with tick antigens elicits immunity to theScience translational medicine · 2025Article
- Transcriptomics insights into the functional role of tick Ixodes ricinus proteins metalloprotease and antigen p23.PloS one · 2025Article
- Vaccination to Prevent Lyme Disease: A Movement Towards Anti-Tick Approaches.The Journal of infectious diseases · 2024Review
- Laboratory Management of Mammalian Hosts forComparative medicine · 2024Review
- Human Tick-Borne Diseases and Advances in Anti-Tick Vaccine Approaches: A Comprehensive Review.Vaccines · 2024Review
- Rabbits as Animal Models for Anti-Tick Vaccine Development: A Global Scenario.Pathogens (Basel, Switzerland) · 2023Review
- Article
- Tick saliva and its role in pathogen transmission.Wiener klinische Wochenschrift · 2023Article
- Recent Advances in Tick Antigen Discovery and Anti-Tick Vaccine Development.International journal of molecular sciences · 2023Review
- Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development.Science (New York, N.Y.) · 2023Article
- A tick C1q protein alters infectivity of the Lyme disease agent by modulating interferon γ.Cell reports · 2022Article
- Tick transmission of Borrelia burgdorferi to the murine host is not influenced by environmentally acquired midgut microbiota.Microbiome · 2022Article
- Review
- The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector.eLife · 2021Article
- Probing an Ixodes ricinus salivary gland yeast surface display with tick-exposed human sera to identify novel candidates for an anti-tick vaccine.Scientific reports · 2021Article
- Structure-function of anticoagulant TIX-5, the inhibitor of factor Xa-mediated FV activation.Journal of thrombosis and haemostasis : JTH · 2021Article
- Acquired tick resistance: The trail is hot.Parasite immunology · 2021Review
- Interactions between Borrelia burgdorferi and its hosts across the enzootic cycle.Parasite immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
Repeated exposure of rabbits and other animals to ticks results in acquired resistance or immunity to subsequent tick bites and is partially elicited by antibodies directed against tick antigens. In this study we demonstrate the utility of a yeast surface display approach to identify tick salivary antigens that react with tick-immune serum. We constructed an Ixodes scapularis nymphal salivary gland yeast surface display library and screened the library with nymph-immune rabbit sera and identified five salivary antigens. Four of these proteins, designated P8, P19, P23 and P32, had a predicted signal sequence. We generated recombinant (r) P8, P19 and P23 in a Drosophila expression system for functional and immunization studies. rP8 showed anti-complement activity and rP23 demonstrated anti-coagulant activity. Ixodes scapularis feeding was significantly impaired when nymphs were fed on rabbits immunized with a cocktail of rP8, rP19 and rP23, a hall mark of tick-immunity. These studies also suggest that these antigens may serve as potential vaccine candidates to thwart tick feeding.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.