ArticleActa histochemica et cytochemica2010
Expression and Role of the BDNF Receptor-TrkB in Rat Adrenal Gland under Acute Immobilization Stress.
Article in Acta histochemica et cytochemica, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Neurotrophomodulatory effect of TNF-α through NF-κB in rat cortical astrocytes.Cytotechnology · 2025Review
- BDNF and its signaling in cancer.Journal of cancer research and clinical oncology · 2023Review
- Brain-derived neurotrophic factor is related to stress and chewing in saliva and salivary glands.The Japanese dental science review · 2020Review
- Article
- Brain-derived neurotrophic factor: A steroidogenic regulator of Leydig cells.Journal of cellular physiology · 2019Article
- Spatiotemporal Differences in Gene Expression Between Motor and Sensory Autografts and Their Effect on Femoral Nerve Regeneration in the Rat.Frontiers in cellular neuroscience · 2019Article
- Salivary Gland Derived BDNF Overexpression in Mice Exerts an Anxiolytic Effect.International journal of molecular sciences · 2017Article
- Cold water swimming pretreatment reduces cognitive deficits in a rat model of traumatic brain injury.Neural regeneration research · 2017Article
- The Effects of Voluntary Physical Exercise-Activated Neurotrophic Signaling in Rat Hippocampus on mRNA Levels of Downstream Signaling Molecules.Journal of molecular neuroscience : MN · 2017Article
- Presence of Functional Neurotrophin TrkB Receptors in the Rat Superior Cervical Ganglion.Frontiers in physiology · 2017Article
- Enhanced BDNF signalling following chronic hypoxia potentiates catecholamine release from cultured rat adrenal chromaffin cells.The Journal of physiology · 2015Article
- Effects of stress on mouse β-defensin-3 expression in the upper digestive mucosa.Yonsei medical journal · 2014Article
- Induction of β-Defensin Expression by Porphyromonas gingivalis-Infected Human Gingival Graft Transplanted in nu/nu Mouse Subdermis.Acta histochemica et cytochemica · 2013Article
- Role of TrkB expression in rat adrenal gland during acute immobilization stress.Journal of neurochemistry · 2013Article
- Anatomy and histology of rodent and human major salivary glands: -overview of the Japan salivary gland society-sponsored workshop-.Acta histochemica et cytochemica · 2012Article
- Role of stress-related brain-derived neurotrophic factor (BDNF) in the rat submandibular gland.Acta histochemica et cytochemica · 2012Article
- Expression and localization of brain-derived neurotrophic factor (BDNF) mRNA and protein in human submandibular gland.Acta histochemica et cytochemica · 2012Article
- Expression and Localization of TRK-Fused Gene Products in the Rat Brain and Retina.Acta histochemica et cytochemica · 2012Article
- Brain-derived neurotrophic factor loop 4 dipeptide mimetic GSB-106 activates TrkB, Erk, and Akt and promotes neuronal survival in vitro.Doklady. Biochemistry and biophysicsArticle
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6 authors.
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Abstract
We reported that plasma brain-derived neurotrophic factor (BDNF) was maximally elevated following a 60-min period of acute immobilization stress and that salivary glands were the main source of plasma BDNF under this stress condition. However, the expression pattern of the BDNF receptor, Tyrosine receptor kinase B (TrkB), under this condition has yet to be determined. We therefore investigated the effect of this stress on the expression level of TrkB in various rat organs using real-time PCR. No significant differences were found between controls and 60 min-stressed rats with respect to TrkB level in various organs. Only adrenal glands showed significantly increased TrkB mRNA levels after 60 min of stress. TrkB mRNA and protein were observed to localize in chromaffin cells. In addition, we investigated whether BDNF-TrkB interaction influences the release of stress hormones from PC12 cells, derived from chromaffin cells. Truncated receptor, TrkB-T1, was identified in PC12 cells using RT-PCR. Exposure of PC12 cells to BDNF induced the release of catecholamine. This BDNF-evoked release was totally blocked by administration of the K252a in which an inhibitor of Trk receptors. Thus, BDNF-TrkB interactions may modulate catecholamine release from adrenal chromaffin cells under acute stress conditions.
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