Trial reportMolecular vision2011
Association of genetic polymorphisms of eNOS with glaucoma.
Trial report in Molecular vision, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The role of polymorphisms rs2070744 and rs1799983 eNOS gene in patients with POAG: a systematic review and meta-analysis.International ophthalmology · 2021Pooled it
- Association of endothelial nitric oxide synthase (NOS3) gene polymorphisms with primary open-angle glaucoma in a Saudi cohort.PloS one · 2020Trial
- Endothelial cell-specific postnatal deletion of Nos3 preserves intraocular pressure homeostasis via macrophage recruitment and NOS2 upregulation.The Journal of clinical investigation · 2025Article
- Silencing microRNA‑29b‑3p expression protects human trabecular meshwork cells against oxidative injury via upregulation of RNF138 to activate the ERK pathway.International journal of molecular medicine · 2021Article
- Muscarinic Acetylcholine Receptors in the Retina-Therapeutic Implications.International journal of molecular sciences · 2021Review
- Updates on Genes and Genetic Mechanisms Implicated in Primary Angle-Closure Glaucoma.The application of clinical genetics · 2021Review
- ABCA1 Regulates IOP by Modulating Cav1/eNOS/NO Signaling Pathway.Investigative ophthalmology & visual science · 2020Article
- Shear Stress in Schlemm's Canal as a Sensor of Intraocular Pressure.Scientific reports · 2020Article
- Pharmacological regulation of outflow resistance distal to Schlemm's canal.American journal of physiology. Cell physiology · 2018Article
- Association of Dietary Nitrate Intake With Primary Open-Angle Glaucoma: A Prospective Analysis From the Nurses' Health Study and Health Professionals Follow-up Study.JAMA ophthalmology · 2016Article
- Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis.Journal of ophthalmology · 2016Article
- Is Estrogen a Therapeutic Target for Glaucoma?Seminars in ophthalmology · 2016Review
- Article
- Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma.Eye (London, England) · 2014Article
- Endothelial nitric oxide synthase polymorphisms and susceptibility to high-tension primary open-angle glaucoma in an Egyptian cohort.Molecular vision · 2014Article
- Association of eNOS polymorphisms with anterior chamber depth in han chinese: jiangsu eye study.Journal of ophthalmology · 2014Article
- Genetics of primary open angle glaucoma.Japanese journal of ophthalmology · 2014Review
- No difference in genotype frequencies of polymorphisms of the nitric oxide pathway between Caucasian normal and high tension glaucoma patients.Molecular vision · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSeveral studies suggest that vascular dysregulation play a role in the etiology of glaucoma. In the present study, we aimed to investigate the association of endothelial nitric oxide synthase (eNOS) gene polymorphisms with primary open angle glaucoma (POAG) and primary closed angle glaucoma (PCAG).
methodsThere were 102 POAG and 88 PCAG patients, diagnosed on the basis of clinical history, raised intraocular pressure (IOP), cup-to-disc ratio (CDR) and visual field defects, and 120 age- and sex-matched control subjects genotyped for 5 tagging single nucleotide polymorphisms (SNPs; rs743507, rs3793342, rs11771443, rs7830, and rs3918188) of the human eNOS gene.
resultsrs3793342, rs743507, rs11771443, rs7830, and rs3918188 were not found to be associated with POAG or with PCAG. In the haplotype-based case-control analysis, the frequency of the C-T haplotype established by rs3793342 and rs11771443 was significantly higher for POAG patients than for control subjects (p<0.001, OR=5.111, 95%CI=1.766~14.788).
conclusionsThe C-T haplotype established by rs3793342 and rs11771443 may be genetic marks of POAG in the Han Chinese population.
Indexed as
Identifiers
21245953PMC3021569W2156487648What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.