ArticlePloS one2011
Exopolysaccharide-independent social motility of Myxococcus xanthus.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Orthogonal microfluidic approaches reveal force-enhanced migration of bacterial populations on surfaces.bioRxiv : the preprint server for biology · 2026Article
- Article
- Physicochemical and Biological Insights Into the Molecular Interactions Between Extracellular DNA and Exopolysaccharides inFrontiers in microbiology · 2022Article
- Conditional and Synthetic Type IV Pili-Dependent Motility Phenotypes inFrontiers in microbiology · 2022Article
- The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Characterization of the Exopolysaccharide Biosynthesis Pathway in Myxococcus xanthus.Journal of bacteriology · 2020Article
- Quantification of Endosome and Lysosome Motilities in Cultured Neurons Using Fluorescent Probes.Journal of visualized experiments : JoVE · 2017Article
- Colony Expansion of Socially Motile Myxococcus xanthus Cells Is Driven by Growth, Motility, and Exopolysaccharide Production.PLoS computational biology · 2016Article
- Stigmergy co-ordinates multicellular collective behaviours during Myxococcus xanthus surface migration.Scientific reports · 2016Article
- Interplay between type IV pili activity and exopolysaccharides secretion controls motility patterns in single cells of Myxococcus xanthus.Scientific reports · 2016Article
- The Matrix Reloaded: Probing the Extracellular Matrix Synchronizes Bacterial Communities.Journal of bacteriology · 2015Article
- Growth of Myxococcus xanthus in continuous-flow-cell bioreactors as a method for studying development.Applied and environmental microbiology · 2014Article
- Earthquake-like dynamics in Myxococcus xanthus social motility.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Characterization of four type IV pilin homologues in Stigmatella aurantiaca DSM17044 by heterologous expression in Myxococcus xanthus.PloS one · 2013Article
- Chemosensory signaling controls motility and subcellular polarity in Myxococcus xanthus.Current opinion in microbiology · 2012Review
- FrzS regulates social motility in Myxococcus xanthus by controlling exopolysaccharide production.PloS one · 2011Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Social motility (S motility), the coordinated movement of large cell groups on agar surfaces, of Myxococcus xanthus requires type IV pili (TFP) and exopolysaccharides (EPS). Previous models proposed that this behavior, which only occurred within cell groups, requires cycles of TFP extension and retraction triggered by the close interaction of TFP with EPS. However, the curious observation that M. xanthus can perform TFP-dependent motility at a single-cell level when placed onto polystyrene surfaces in a highly viscous medium containing 1% methylcellulose indicated that "S motility" is not limited to group movements. In an apparent further challenge of the previous findings for S motility, mutants defective in EPS production were found to perform TFP-dependent motility on polystyrene surface in methylcellulose-containing medium. By exploring the interactions between pilin and surface materials, we found that the binding of TFP onto polystyrene surfaces eliminated the requirement for EPS in EPS(-) cells and thus enabled TFP-dependent motility on a single cell level. However, the presence of a general anchoring surface in a viscous environment could not substitute for the role of cell surface EPS in group movement. Furthermore, EPS was found to serve as a self-produced anchoring substrate that can be shed onto surfaces to enable cells to conduct TFP-dependent motility regardless of surface properties. These results suggested that in certain environments, such as in methylcellulose solution, the cells could bypass the need for EPS to anchor their TPF and conduct single-cell S motility to promote exploratory movement of colonies over new specific surfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.