ArticlePLoS neglected tropical diseases2011
Subacute sclerosing panencephalitis in papua new guinean children: the cost of continuing inadequate measles vaccine coverage.
Article in PLoS neglected tropical diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Positive Impact of Vaccinal Status Among Notified Measles Cases in Romania in 2020-2024.Epidemiologia (Basel, Switzerland) · 2025Article
- A Case of Measles Virus-caused Subacute Sclerosing Panencephalitis Diagnosed by Molecular and Clinical Analysis.Open forum infectious diseases · 2025Article
- Article
- Fatal subacute sclerosing panencephalitis in an 8-year-old male: a case report.The Pan African medical journal · 2023Article
- Effectiveness of immunization activities on measles and rubella immunity among individuals in East Sepik, Papua New Guinea: A cross-sectional study.IJID regions · 2022Article
- The epidemiology and outcomes of central nervous system infections in Far North Queensland, tropical Australia; 2000-2019.PloS one · 2022Article
- Options in the Treatment of Subacute Sclerosing Panencephalitis: Implications for Low Resource Areas.Current treatment options in neurology · 2022Review
- Estimating Child Mortality at the Sub-national Level in Papua New Guinea: Evidence From the Integrated Health and Demographic Surveillance System.Frontiers in public health · 2021Article
- Fulminant subacute sclerosing panencephalitis in an immunized 20-month-old Indian boy.Neurosciences (Riyadh, Saudi Arabia) · 2018Article
- Subacute sclerosing panencephalitis - current perspectives.Pediatric health, medicine and therapeutics · 2018Review
- Synthesis of Evidence to Characterize National Measles and Rubella Exposure and Immunization Histories.Risk analysis : an official publication of the Society for Risk Analysis · 2016Article
- Viral pathogens in children hospitalized with features of central nervous system infection in a malaria-endemic region of Papua New Guinea.BMC infectious diseases · 2014Article
- Prevalence and implications of cerebrospinal fluid leukocytosis in Papua New Guinean children hospitalized with severe malaria.The American journal of tropical medicine and hygiene · 2013Article
- Ethical challenges in integrating patient-care with clinical research in a resource-limited setting: perspectives from Papua New Guinea.BMC medical ethics · 2013Article
- Severe anemia in Papua New Guinean children from a malaria-endemic area: a case-control etiologic study.PLoS neglected tropical diseases · 2012Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionsubacute sclerosing panencephalitis (SSPE) is a late, rare and usually fatal complication of measles infection. Although a very high incidence of SSPE in Papua New Guinea (PNG) was first recognized 20 years ago, estimated measles vaccine coverage has remained at ≤ 70% since and a large measles epidemic occurred in 2002. We report a series of 22 SSPE cases presenting between November 2007 and July 2009 in Madang Province, PNG, including localized clusters with the highest ever reported annual incidence. METHODOLOGY/PRINCIPAL
findingsas part of a prospective observational study of severe childhood illness at Modilon Hospital, the provincial referral center, children presenting with evidence of meningo-encephalitis were assessed in detail including lumbar puncture in most cases. A diagnosis of SSPE was based on clinical features and presence of measles-specific IgG in cerebrospinal fluid and/or plasma. The estimated annual SSPE incidence in Madang province was 54/million population aged <20 years, but four sub-districts had an incidence >100/million/year. The distribution of year of birth of the 22 children with SSPE closely matched the reported annual measles incidence in PNG, including a peak in 2002. CONCLUSIONS/SIGNIFICANCE: SSPE follows measles infections in very young PNG children. Because PNG children have known low seroconversion rates to the first measles vaccine given at 6 months of age, efforts such as supplementary measles immunisation programs should continue in order to reduce the pool of non-immune people surrounding the youngest and most vulnerable members of PNG communities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.