ArticlePloS one2011
Repulsive forces between looping chromosomes induce entropy-driven segregation.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Article
- DNA sliding and loop formation byBiochemistry and biophysics reports · 2022Article
- A Lamin-Associated Chromatin Model for Chromosome Organization.Biophysical journal · 2020Article
- Article
- Article
- Computational 3D genome modeling using Chrom3D.Nature protocols · 2018Article
- Differential chromosome conformations as hallmarks of cellular identity revealed by mathematical polymer modeling.PLoS computational biology · 2015Article
- Quantified effects of chromosome-nuclear envelope attachments on 3D organization of chromosomes.Nucleus (Austin, Tex.) · 2015Article
- Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction: insight into chromatin folding by polymer modelling.PLoS computational biology · 2014Article
- DNA double-strand breaks: linking gene expression to chromosome morphology and mobility.Chromosoma · 2014Article
- Investigation of the chromosome regions with significant affinity for the nuclear envelope in fruit fly--a model based approach.PloS one · 2014Article
- Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data.Nature reviews. Genetics · 2013Review
- Chromosome segregation by the Escherichia coli Min system.Molecular systems biology · 2013Article
- Expression-dependent folding of interphase chromatin.PloS one · 2012Article
- Article
- Chromatin: constructing the big picture.The EMBO journal · 2011Review
- Centromeres: unique chromatin structures that drive chromosome segregation.Nature reviews. Molecular cell biology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One striking feature of chromatin organization is that chromosomes are compartmentalized into distinct territories during interphase, the degree of intermingling being much smaller than expected for linear chains. A growing body of evidence indicates that the formation of loops plays a dominant role in transcriptional regulation as well as the entropic organization of interphase chromosomes. Using a recently proposed model, we quantitatively determine the entropic forces between chromosomes. This Dynamic Loop Model assumes that loops form solely on the basis of diffusional motion without invoking other long-range interactions. We find that introducing loops into the structure of chromatin results in a multi-fold higher repulsion between chromosomes compared to linear chains. Strong effects are observed for the tendency of a non-random alignment; the overlap volume between chromosomes decays fast with increasing loop number. Our results suggest that the formation of chromatin loops imposes both compartmentalization as well as order on the system without requiring additional energy-consuming processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.