ArticleEuropean journal of clinical nutrition2011
Relationship of folate, vitamin B12 and methylation of insulin-like growth factor-II in maternal and cord blood.
Article in European journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation.Epigenetics · 2023Pooled it
- Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review.Annals of global health · 2018Pooled it
- Associations between body size, nutrition and socioeconomic position in early life and the epigenome: A systematic review.PloS one · 2018Pooled it
- Dietary supplementation with polyunsaturated fatty acid during pregnancy modulates DNA methylation at IGF2/H19 imprinted genes and growth of infants.Physiological genomics · 2014Trial
- Placental DNA methylation key topics: sex- and cell-type specificity, mediation, multi-omics, and biomarker discovery.Epigenomics · 2025Review
- Maternal Periconceptional Folic Acid Supplementation and DNA Methylation Patterns in Adolescent Offspring.The Journal of nutrition · 2023Article
- Epigenetic Effect of Maternal Methyl-Group Donor Intake on Offspring's Health and Disease.Life (Basel, Switzerland) · 2022Review
- Article
- Maternal tobacco smoke exposure is associated with increased DNA methylation at human metastable epialleles in infant cord blood.Environmental epigenetics · 2022Article
- Folate Carrier Deficiency Drives Differential Methylation and Enhanced Cellular Potency in the Neural Plate Border.Frontiers in cell and developmental biology · 2022Article
- Maternal Dietary Quality and Dietary Inflammation Associations with Offspring Growth, Placental Development, and DNA Methylation.Nutrients · 2021Review
- Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the Generation R Study.Clinical epigenetics · 2021Article
- Article
- Altered Cortical Brain Structure and Increased Risk for Disease Seen Decades After Perinatal Exposure to Maternal Smoking: A Study of 9000 Adults in the UK Biobank.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study.Clinical epigenetics · 2019Article
- Review
- Dietary exposures, epigenetics and pubertal tempo.Environmental epigenetics · 2019Article
- Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism.International journal of epidemiology · 2018Review
- Maternal vitamin D, DNA methylation at imprint regulatory regions and offspring weight at birth, 1 year and 3 years.International journal of obesity (2005) · 2018Article
- Identifying and correcting epigenetics measurements for systematic sources of variation.Clinical epigenetics · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
objectiveOne of the speculated mechanisms underlying fetal origin hypothesis of breast cancer is the possible influence of maternal environment on epigenetic regulation, such as changes in DNA methylation of the insulin-like growth factor-2 (IGF2) gene. The aim of the study is to investigate the relationship between folate, vitamin B(12) and methylation of the IGF2 gene in maternal and cord blood. SUBJECTS/
methodsWe conducted a cross-sectional study to measure methylation patterns of IGF2 in promoters 2 (P2) and promoters 3 (P3).
resultsThe percentage of methylation in IGF2 P3 was higher in maternal blood than in cord blood (P<0.0001), whereas the methylation in P2 was higher in cord blood than in maternal blood (P=0.016). P3 methylation was correlated between maternal and cord blood (P<0.0001), but not P2 (P=0.06). The multivariate linear regression model showed that methylation patterns of both promoters in cord blood were not associated with serum folate levels in either cord or maternal blood, whereas the P3 methylation patterns were associated with serum levels of vitamin B(12) in mother's blood (mean change (MC)=-0.22, P=0.0014). Methylation patterns in P2 of maternal blood were associated with serum levels of vitamin B(12) in mother's blood (MC=-0.23, P=0.012), exposure to passive smoking (MC=0.46, P=0.034) and mother's weight gain during pregnancy (MC=0.23, P=0.019).
conclusionsThe study suggests that environment influences methylation patterns in maternal blood, and then the maternal patterns influence the methylation status and levels of folate and vitamin B(12) in cord blood.
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Registered trials
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