Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2011
Pseudocontinuous arterial spin labeling reveals dissociable effects of morphine and alcohol on regional cerebral blood flow.
Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Reproducibility of pharmacological ASL using sequences from different vendors: implications for multicenter drug studies.Magma (New York, N.Y.) · 2015Trial
- Dose-dependent effects of intravenous alcohol administration on cerebral blood flow in young adults.Psychopharmacology · 2015Trial
- Alcohol-induced impairment of inhibitory control is linked to attenuated brain responses in right fronto-temporal cortex.Biological psychiatry · 2014Trial
- In vivo assessment of human brainstem cerebrovascular function: a multi-inversion time pulsed arterial spin labelling study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Trial
- Acute effects of alcohol on brain perfusion monitored with arterial spin labeling magnetic resonance imaging in young adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Trial
- Spatial heterogeneity of the relation between resting-state connectivity and blood flow: an important consideration for pharmacological studies.Human brain mapping · 2014Trial
- Quantifying cerebellum grey matter and white matter perfusion using pulsed arterial spin labeling.BioMed research international · 2014Trial
- Imaging drugs with and without clinical analgesic efficacy.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Trial
- Psilocybin-induced changes in cerebral blood flow are associated with acute and baseline inter-individual differences.Scientific reports · 2023Article
- Blunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment.Alcohol, clinical & experimental research · 2023Article
- Application of Magnetic Resonance Imaging in the Evaluation of Nutritional Status: A Literature Review with Focus on Dialysis Patients.Nutrients · 2021Review
- The Relationship Between Regional Cerebral Blood Flow Estimates and Alcohol Problems at 5-Year Follow-Up: The Role of Level of Response.Alcoholism, clinical and experimental research · 2019Article
- Effects of Acute Alcohol Consumption on the Human Brain: Diffusional Kurtosis Imaging and Arterial Spin-Labeling Study.AJNR. American journal of neuroradiology · 2019Article
- Cerebral Blood Flow Measurements in Adults: A Review on the Effects of Dietary Factors and Exercise.Nutrients · 2018Review
- Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry.Human brain mapping · 2017Review
- Resting-state regional cerebral blood flow during adolescence: associations with initiation of substance use and prediction of future use disorders.Drug and alcohol dependence · 2015Article
- Dopaminergic system dysfunction in recreational dexamphetamine users.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs.PloS one · 2014Article
- A selective insular perfusion deficit contributes to compromised salience network connectivity in recovering alcoholic men.Biological psychiatry · 2013Article
- Neuropsychological Functions of μ- and δ-Opioid Systems.ISRN Addiction · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have examined sensitivity and specificity of pseudocontinuous arterial spin labeling (PCASL) to detect global and regional changes in cerebral blood flow (CBF) in response to two different psychoactive drugs. We tested alcohol and morphine in a placebo-controlled, double-blind randomized study in 12 healthy young men. Drugs were administered intravenously. Validated pharmacokinetic protocols achieved minimal intersubject and intrasubject variance in plasma drug concentration. Permutation-based statistical testing of a mixed effect repeated measures model revealed a widespread increase in absolute CBF because of both morphine and alcohol. Conjunction analysis revealed overlapping effects of morphine and alcohol on absolute CBF in the left anterior cingulate, right hippocampus, right insula, and left primary sensorimotor areas. Effects of morphine and alcohol on relative CBF (obtained from z-normalization of absolute CBF maps) were significantly different in the left putamen, left frontoparietal network, cerebellum, and the brainstem. Corroborating previous PET results, our findings suggest that PCASL is a promising tool for central nervous system drug research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.