ArticleMolecular systems biology2011
Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery.
Article in Molecular systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed.
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- hiPSCGEM01: A Genome-Scale Metabolic Model for Fibroblast-Derived Human iPSCs.Bioengineering (Basel, Switzerland) · 2025Article
- Accurate prediction of gene deletion phenotypes with Flux Cone Learning.Nature communications · 2025Article
- Screening of Potential Drug Targets Based on the Genome-Scale Metabolic Network Model ofCurrent issues in molecular biology · 2025Article
- Reconstruction and Analysis of a Genome-Scale Metabolic Model ofInternational journal of molecular sciences · 2024Article
- Prediction of metabolites associated with somatic mutations in cancers by using genome-scale metabolic models and mutation data.Genome biology · 2024Article
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- A Protocol for the Automatic Construction of Highly Curated Genome-Scale Models of Human Metabolism.Bioengineering (Basel, Switzerland) · 2023Article
- Vibrio natriegens genome-scale modeling reveals insights into halophilic adaptations and resource allocation.Molecular systems biology · 2023Article
- Genome-scale model of Pseudomonas aeruginosa metabolism unveils virulence and drug potentiation.Communications biology · 2023Article
- A Computational Toolbox to Investigate the Metabolic Potential and Resource Allocation in Fission Yeast.mSystems · 2022Article
- Rapid-SL identifies synthetic lethal sets with an arbitrary cardinality.Scientific reports · 2022Article
- Distribution, Phylogeny and Evolution of Clinical and EnvironmentalEvolutionary bioinformatics online · 2022Article
- Towards a Systems Biology Approach to Understanding the Lichen Symbiosis: Opportunities and Challenges of Implementing Network Modelling.Frontiers in microbiology · 2021Review
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- Antibiotic resistance: Time of synthesis in a post-genomic age.Computational and structural biotechnology journal · 2021Review
- Reconstructing organisms in silico: genome-scale models and their emerging applications.Nature reviews. Microbiology · 2020Review
- Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi.PLoS neglected tropical diseases · 2020Article
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26 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
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Abstract
Although the genomes of many microbial pathogens have been studied to help identify effective drug targets and novel drugs, such efforts have not yet reached full fruition. In this study, we report a systems biological approach that efficiently utilizes genomic information for drug targeting and discovery, and apply this approach to the opportunistic pathogen Vibrio vulnificus CMCP6. First, we partially re-sequenced and fully re-annotated the V. vulnificus CMCP6 genome, and accordingly reconstructed its genome-scale metabolic network, VvuMBEL943. The validated network model was employed to systematically predict drug targets using the concept of metabolite essentiality, along with additional filtering criteria. Target genes encoding enzymes that interact with the five essential metabolites finally selected were experimentally validated. These five essential metabolites are critical to the survival of the cell, and hence were used to guide the cost-effective selection of chemical analogs, which were then screened for antimicrobial activity in a whole-cell assay. This approach is expected to help fill the existing gap between genomics and drug discovery.
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