ArticleThe Indian journal of medical research2010
Attenuation of oxidative stress & DNA damage in varicocelectomy: implications in infertility management.
Article in The Indian journal of medical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
- Evaluation of the effects of antioxidant treatment on sperm parameters and pregnancy rates in infertile patients after varicocelectomy: a randomized controlled trial.International journal of impotence research · 2019Trial
- Article
- Is varicocele repair justified in infertile men with clinical varicocele, normal conventional semen parameters and elevated sperm DNA fragmentation (SDF)?Arab journal of urology · 2025Review
- Effects of Varicocele Repair on Sperm DNA Fragmentation and Seminal Malondialdehyde Levels in Infertile Men with Clinical Varicocele: A Systematic Review and Meta-Analysis.The world journal of men's health · 2024Article
- The role of seminal reactive oxygen species assessment in the setting of infertility and early pregnancy loss.World journal of urology · 2023Article
- Oxidative Stress and Cell Cycle Arrest in Seminiferous Tubules Nearby Varicose Vessels: New Perspectives from Experimental Varicocele.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- The Role and Place of Antioxidants in the Treatment of Male Infertility Caused by Varicocele.Journal of clinical medicine · 2022Article
- Oxidative Stress and Varicocele-Associated Male Infertility.Advances in experimental medicine and biology · 2022Article
- Oxidative Stress: A Comprehensive Review of Biochemical, Molecular, and Genetic Aspects in the Pathogenesis and Management of Varicocele.The world journal of men's health · 2022Review
- Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility.The world journal of men's health · 2019Review
- Should we expand the indications for varicocele treatment?Translational andrology and urology · 2017Review
- Genetics and epigenetics of varicocele pathophysiology: an overview.Journal of assisted reproduction and genetics · 2017Review
- Novel concepts in male factor infertility: clinical and laboratory perspectives.Journal of assisted reproduction and genetics · 2016Review
- Oxidation-reduction potential of semen: what is its role in the treatment of male infertility?Therapeutic advances in urology · 2016Review
- Sperm nuclear vacuoles in relation to acrosome reactions and sperm motility.TheScientificWorldJournal · 2014Article
- Observation of spermatozoa by a high-magnification microscope.Reproductive medicine and biology · 2014Review
- Insight into oxidative stress in varicocele-associated male infertility: part 2.Nature reviews. Urology · 2013Review
- Improving metabolic health in obese male mice via diet and exercise restores embryo development and fetal growth.PloS one · 2013Article
- Expression of cyclooxygenase-1 (COX-1) and COX-2 in human male gametes from normal patients, and those with varicocele and diabetes: a potential molecular marker for diagnosing male infertility disorders.Journal of anatomy · 2012Article
- Increased sperm DNA damage in experimental rat varicocele model and the beneficial effect of varicocelectomy.International journal of fertility & sterility · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sperm DNA integrity is of vital importance for foetal development and birth of healthy offspring. Oxidative stress and consequent DNA damage are the major cause of decline in semen quality in men with varicocele. A preliminary study was conducted on 11 men with clinical varicocele who also had high levels of reactive oxygen species (ROS), to assess DNA damage in sperms and ROS levels before and after varicocelectomy. Varicocelectomy resulted in rapid (1 month) significant (P<0.001) decline in free radical levels and slow (3-6 months) significant decline in DNA damage levels. Thus men undergoing varicocelectomy should try concieving only 6 months following surgery.
Indexed as
Identifiers
21245622PMC3102462W2113620421What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.