ArticleThe Indian journal of medical research2010
Epidemiology of hepatitis C virus infection & liver disease among injection drug users (IDUs) in Chennai, India.
Article in The Indian journal of medical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Transmission of hepatitis C virus infection through tattooing and piercing: a critical review.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Pooled it
- Hepatitis C and HIV co-infection, viral load, and liver enzyme profiles among intravenous and non-intravenous drug users in Jorhat, Assam: a comparative analysis.BMC infectious diseases · 2026Article
- Sociodemographic and clinical profiles of individuals with opioid dependence syndrome presenting to a tertiary care center in Assam: A retrospective review.Indian journal of psychiatry · 2024Article
- Socio-demographic association with confirmed hepatitis C virus infection: A cross-sectional analysis from a teaching institute.Journal of family medicine and primary care · 2024Article
- Antibody avidity-based approach to estimate population-level incidence of hepatitis C.Journal of hepatology · 2020Article
- Deriving the optimal limit of detection for an HCV point-of-care test for viraemic infection: Analysis of a global dataset.Journal of hepatology · 2019Article
- Cost of Intensive Care Treatment for Liver Disorders at Tertiary Care Level in India.PharmacoEconomics - open · 2018Article
- Assessment of clinical co-morbidities.Indian journal of psychiatry · 2018Review
- Tackling the Hepatitis C Disease Burden in Punjab, India.Journal of clinical and experimental hepatology · 2016Review
- Morbidity and Mortality Among Community-Based People Who Inject Drugs With a High Hepatitis C and Human Immunodeficiency Virus Burden in Chennai, India.Open forum infectious diseases · 2016Article
- Drug Abuse, HIV, and HCV in Asian Countries.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Review
- HIV, Hepatitis B and C among people who inject drugs: high prevalence of HIV and Hepatitis C RNA positive infections observed in Delhi, India.BMC public health · 2015Article
- Burden of hepatitis C virus disease and access to hepatitis C virus services in people who inject drugs in India: a cross-sectional study.The Lancet. Infectious diseases · 2015Article
- Consensus Statement of HCV Task Force of the Indian National Association for Study of the Liver (INASL). Part I: Status Report of HCV Infection in India.Journal of clinical and experimental hepatology · 2014Review
- Clinical chemistry profiles in injection heroin users from Coastal Region, Kenya.BMC clinical pathology · 2014Article
- A new era in the treatment of chronic hepatitis C infection.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2013Review
- Factors associated with injection cessation, relapse and initiation in a community-based cohort of injection drug users in Chennai, India.Addiction (Abingdon, England) · 2012Article
- The journey of opioid substitution therapy in India: Achievements and challenges.Indian journal of psychiatryArticle
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectivesWe characterized HCV antibody prevalence, viral persistence, genotype and liver disease prevalence among IDUs in Chennai, India as the study of the association of HIV with each of these states is important and there are no data available.
methodsBetween 2005-2006, 1158 IDUs were recruited and followed semi-annually. All were tested for HCV antibodies at baseline; a random sample of 400 antibody positives (200 HIV-positive and 200 HIV-negative) were tested for HCV RNA; 13 of these were sequenced. Assessment of asparate amino transferase (AST)-to-platelet ratio index (APRI) was done on 557 IDUs. Prevalence ratios of each outcome were examined.
resultsMedian age was 35 yr; 99 per cent were male. HCV antibody prevalence was 55 per cent and was associated with older age, being unmarried, longer injection history, tattoo and injecting at a dealer's place. Of the 400 HCV antibody positive IDUs, 281 (70.3%) had persistent infection which was less common among hepatitis B-infected persons but not associated with HIV. Of the 13 samples sequenced, 11 (85%) were HCV genotype 3a. Fibrosis prevalence according to APRI was: HIV/HCV-uninfected, 4 per cent; HIV mono-infected, 3 per cent; HCV mono-infected, 11 per cent; HIV/HCV co-infected, 12 per cent (P<0.001). In addition to being associated with HCV and HIV/HCV, fibrosis prevalence was higher among those drinking alcohol frequently; daily marijuana use was protective. INTERPRETATION AND
conclusionsOur findings show that IDUs in Chennai have high HCV prevalence and associated disease burden. The burden will increase as access to antiretroviral therapy improves particularly given the high prevalence of HIV, HCV and alcohol use.
Indexed as
Identifiers
21245619PMC3102459W2096497201What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.