ArticleAntimicrobial agents and chemotherapy2011
Time-kill activity of the streptogramin NXL 103 against Gram-positive and -negative bacteria.
Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- The post antibiotic effect of streptogramins on gram-positive bacteria primarily arises from the type a component.Microbial pathogenesis · 2026Article
- Treatment of MRSA Infection: Where are We?Current medicinal chemistry · 2024Review
- Modular Chemical Synthesis of Streptogramin and Lankacidin Antibiotics.Accounts of chemical research · 2021Article
- Modular synthesis of streptogramin antibiotics.Synlett : accounts and rapid communications in synthetic organic chemistry · 2021Article
- A concise route to virginiamycin M2.Tetrahedron · 2019Article
- The Mechanisms of Action of Ribosome-Targeting Peptide Antibiotics.Frontiers in molecular biosciences · 2018Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Against 33 Gram-positive and -negative bacteria, NXL 103 MICs were 0.03 to 1 μg/ml. NXL 103 was bactericidal by 12 h at 2 × MIC against all 5 pneumococci and at 2 × MIC after 24 h against all 5 group A and B β-hemolytic streptococci. NXL 103 was bactericidal against all 8 Haemophilus influenzae strains at 2 × MIC and all 5 Moraxella catarrhalis strains at 4 × MIC after 24 h but was mainly bacteriostatic against 5 methicillin-resistant Staphylococcus aureus strains. After the exposure of one strain of each species to NXL 103 for 10 daily subcultures, the MICs remained within ± 1 dilution.
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