ArticleInvestigative ophthalmology & visual science2011
Distortion of axonal cytoskeleton: an early sign of glaucomatous damage.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Increase of retinal layer thickness in a rat model of acute intraocular hypertension.Experimental eye research · 2026Article
- Truncation mutations in MYRF underlie primary angle closure glaucoma.Human genetics · 2023Article
- Adaptive optics scanning laser ophthalmoscopy may support early diagnosis of glaucoma.Indian journal of ophthalmology · 2022Article
- The Role of Axonal Transport in Glaucoma.International journal of molecular sciences · 2022Review
- Axon injury signaling and compartmentalized injury response in glaucoma.Progress in retinal and eye research · 2019Review
- Longitudinal detection of retinal alterations by visible and near-infrared optical coherence tomography in a dexamethasone-induced ocular hypertension mouse model.Neurophotonics · 2019Article
- Temporal change of retinal nerve fiber layer reflectance speckle in normal and hypertensive retinas.Experimental eye research · 2019Article
- Response of the Retinal Nerve Fiber Layer Reflectance and Thickness to Optic Nerve Crush.Investigative ophthalmology & visual science · 2018Article
- Novel Technique for Quantifying Retinal Nerve Fiber Bundle Abnormality in the Temporal Raphe.Optometry and vision science : official publication of the American Academy of Optometry · 2018Article
- Asymmetry of Peak Thicknesses between the Superior and Inferior Retinal Nerve Fiber Layers for Early Glaucoma Detection: A Simple Screening Method.Yonsei medical journal · 2018Article
- Cross-linked actin networks (CLANs) in glaucoma.Experimental eye research · 2017Review
- Cytoskeletal Alteration and Change of Retinal Nerve Fiber Layer Birefringence in Hypertensive Retina.Current eye research · 2017Article
- Reflectance Spectrum and Birefringence of the Retinal Nerve Fiber Layer With Hypertensive Damage of Axonal Cytoskeleton.Investigative ophthalmology & visual science · 2017Article
- Structural and Functional Evaluations for the Early Detection of Glaucoma.Expert review of ophthalmology · 2016Article
- Retinal nerve fiber layer reflectometry must consider directional reflectance.Biomedical optics express · 2016Article
- Early Cytoskeletal Protein Modifications Precede Overt Structural Degeneration in the DBA/2J Mouse Model of Glaucoma.Frontiers in neuroscience · 2016Article
- In vivo imaging methods to assess glaucomatous optic neuropathy.Experimental eye research · 2015Review
- Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice.Molecular neurodegeneration · 2014Article
- Classification of axonal subtypes based on cytoskeletal components.Cell health and cytoskeleton · 2014Article
- Wavelength-dependent change of retinal nerve fiber layer reflectance in glaucomatous retinas.Investigative ophthalmology & visual science · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeGlaucoma damages the retinal nerve fiber layer (RNFL). The purpose of this study was to investigate the distribution of major cytoskeleton components, F-actin, microtubules (MTs), and neurofilaments (NFs), in the RNFL during the development of glaucoma. methods: Intraocular hypertension was induced in a rat model by laser photocoagulation of the trabecular meshwork. Retinas were obtained after 2 to 3.5 weeks of treatment. Multiple fluorescent stains were used to identify F-actin, MTs, NFs, and nuclei simultaneously in the same tissue. Distribution of these components in a whole-mounted retina was examined by confocal microscopy. Fluorescent stain was quantitatively described.
resultsIn normal RNFL F-actin, MTs, and NFs were intensely stained. Along the bundles, F-actin and MTs were strongly colocalized, but alternating strands of F-actin and NFs were apparent. Normal RNFL lacked nuclei. In glaucomatous retinas, irregular staining of F-actin, MTs, and NFs was found within the bundles. A strong network of F-actin appeared on the RNFL surface and between the bundles. In severely damaged retinal regions total loss of F-actin and MTs was found, whereas residual strands of NFs were evident. Before the decrease in RNFL thickness, irregularity of F-actin stain and density of nuclei in the RNFL significantly increased.
conclusionsThe results suggest that F-actin, MTs, and NFs are rich and approximately uniformly distributed in the normal RNFL. Glaucoma causes alteration of the cytoskeleton in the RNFL. F-actin is the most sensitive component in its response to stress on the retina. An increase in the number of nuclei in the RNFL may be an early sign of glaucomatous damage.
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