ArticleMolecular and cellular biology2011
Novel core promoter elements and a cognate transcription factor in the divergent unicellular eukaryote Trichomonas vaginalis.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 39 citations in OpenAlex.
- Analysis ofMicroorganisms · 2026Article
- Influence of DNA methylation and chromatin accessibility on regulation of gene expression duringmBio · 2026Article
- Chromatin accessibility and gene expression in the parasite Trichomonas vaginalis.BMC infectious diseases · 2025Article
- The Non-Canonical Iron-Responsive Element of IRE-tvcp12 Hairpin Structure at the 3'-UTR ofPathogens (Basel, Switzerland) · 2023Article
- Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs.Pharmaceuticals (Basel, Switzerland) · 2023Review
- In-depth comparative analysis of Tritrichomonas foetus transcriptomics reveals novel genes linked with adaptation to feline host.Scientific reports · 2022Article
- Recent advances in the molecular biology of the protist parasiteFaculty reviews · 2021Review
- Determinants of translation efficiency in the evolutionarily-divergent protist Trichomonas vaginalis.BMC molecular and cell biology · 2020Article
- Adenine DNA methylation, 3D genome organization, and gene expression in the parasiteProceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Oxymonad Genome Displays Canonical Eukaryotic Complexity in the Absence of a Mitochondrion.Molecular biology and evolution · 2019Article
- An in vitro characterisation of the Trichomonas vaginalis TATA box-binding proteins (TBPs).Parasitology research · 2019Article
- Spliceosomal introns in Trichomonas vaginalis revisited.Parasites & vectors · 2018Article
- A secreted Heat shock protein 90 of Trichomonas vaginalis.PLoS neglected tropical diseases · 2018Article
- Recent Advances in the Trichomonas vaginalis Field.F1000Research · 2016Review
- RNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional Proteins.Biomolecules · 2015Review
- Trichomonas vaginalis Cysteine Proteinases: Iron Response in Gene Expression and Proteolytic Activity.BioMed research international · 2015Review
- The parasite Trichomonas vaginalis expresses thousands of pseudogenes and long non-coding RNAs independently from functional neighbouring genes.BMC genomics · 2014Article
- What is the importance of zoonotic trichomonads for human health?Trends in parasitology · 2014Review
- Novel core promoter elements in the oomycete pathogen Phytophthora infestans and their influence on expression detected by genome-wide analysis.BMC genomics · 2013Article
- Regulation of H2O2 stress-responsive genes through a novel transcription factor in the protozoan pathogen Entamoeba histolytica.The Journal of biological chemistry · 2013Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
A highly conserved DNA initiator (Inr) element has been the only core promoter element described in the divergent unicellular eukaryote Trichomonas vaginalis, although genome analyses reveal that only ∼75% of protein-coding genes appear to contain an Inr. In search of another core promoter element(s), a nonredundant database containing 5' untranslated regions of expressed T. vaginalis genes was searched for overrepresented DNA motifs and known eukaryotic core promoter elements. In addition to identifying the Inr, two elements that lack sequence similarity to the known protein-coding gene core promoter, motif 3 (M3) and motif 5 (M5), were identified. Mutational and functional analyses demonstrate that both are novel core promoter elements. M3 [(A/G/T)(A/G)C(G/C)G(T/C)T(T/A/G)] resembles a Myb recognition element (MRE) and is bound specifically by a unique protein with a Myb-like DNA binding domain. The M5 element (CCTTT) overlaps the transcription start site and replaces the Inr as an alternative, gene-specific initiator element. Transcription specifically initiates at the second cytosine within M5, in contrast to characteristic initiation by RNA polymerase II at an adenosine. In promoters that combine M3 with either M5 or Inr, transcription initiation is regulated by the M3 motif.
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Registered trials
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