Trial reportClinical chemistry2011
Maternal methadone dose, placental methadone concentrations, and neonatal outcomes.
Trial report in Clinical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Fetal assessment before and after dosing with buprenorphine or methadone.Addiction (Abingdon, England) · 2012Trial
- Preliminary buprenorphine sublingual tablet pharmacokinetic data in plasma, oral fluid, and sweat during treatment of opioid-dependent pregnant women.Therapeutic drug monitoring · 2011Trial
- Reviewing the Impact of Maternal Opioid Use Disorder on Fetal Development and Long-Term Pediatric Health Outcomes.Cureus · 2024Review
- Investigating the neurobiology of maternal opioid use disorder and prenatal opioid exposure using brain organoid technology.Frontiers in cellular neuroscience · 2024Review
- Methadone alters transcriptional programs associated with synapse formation in human cortical organoids.Translational psychiatry · 2023Article
- Association of medication-assisted treatment and short acting opioids with newborn head circumference and birth weight.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- The placenta as a target of opioid drugs†.Biology of reproduction · 2022Review
- Neuroimaging in infants with prenatal opioid exposure: Current evidence, recent developments and targets for future research.Journal of neuroradiology = Journal de neuroradiologie · 2021Review
- Methadone Suppresses Neuronal Function and Maturation in Human Cortical Organoids.Frontiers in neuroscience · 2020Article
- Risk Factors Associated with the Occurrence of Neonatal Opioid Withdrawal Syndrome: A Review.CNS drugs · 2019Review
- Neonatal abstinence syndrome.Nature reviews. Disease primers · 2018Review
- Screening Pregnant Women and Their Neonates for Illicit Drug Use: Consideration of the Integrated Technical, Medical, Ethical, Legal, and Social Issues.Frontiers in pharmacology · 2018Review
- Will Widespread Synthetic Opioid Consumption Induce Epigenetic Consequences in Future Generations?Frontiers in pharmacology · 2018Review
- Oral morphine weaning for neonatal abstinence syndrome at home compared with in-hospital: an observational cohort study.Paediatric drugs · 2015Article
- Beneficial effects of co-treatment with dextromethorphan on prenatally methadone-exposed offspring.Journal of biomedical science · 2015Article
- A Multidisciplinary Approach to the Treatment of Co-occurring Opioid Use Disorder and Posttraumatic Stress Disorder in Pregnancy: A Case Report.Journal of dual diagnosis · 2015Article
- Obstetric Pharmacokinetic Dosing Studies are Urgently Needed.Frontiers in pediatrics · 2014Review
- The opioid system and brain development: effects of methadone on the oligodendrocyte lineage and the early stages of myelination.Developmental neuroscience · 2014Article
- Methadone and metabolites in hair of methadone-assisted pregnant women and their infants.Therapeutic drug monitoring · 2012Article
- Treating Women Who Are Pregnant and Parenting for Opioid Use Disorder and the Concurrent Care of Their Infants and Children: Literature Review to Support National Guidance.Journal of addiction medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundFew investigations have used placenta as an alternative matrix to detect in utero drug exposure, despite its availability at the time of birth and the large amount of sample. Methadone-maintained opioid-dependent pregnant women provide a unique opportunity to examine the placental disposition of methadone and metabolite [2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP)], to explore their correlations with maternal methadone dose and neonatal outcomes, and to test the ability to detect in utero exposure to illicit drugs.
methodsWe calculated the correlations of placental methadone and EDDP concentrations and their correlations with maternal methadone doses and neonatal outcomes. Cocaine- and opiate-positive placenta results were compared with the results for meconium samples and for urine samples collected throughout gestation.
resultsPositive correlations were found between placental methadone and EDDP concentrations (r=0.685), and between methadone concentration and methadone dose at delivery (r=0.542), mean daily dose (r=0.554), mean third-trimester dose (r=0.591), and cumulative daily dose (r=0.639). The EDDP/methadone concentration ratio was negatively correlated with cumulative daily dose (r=-0.541) and positively correlated with peak neonatal abstinence syndrome (NAS) score (r=0.513). Placental EDDP concentration was negatively correlated with newborn head circumference (r=-0.579). Cocaine and opiate use was detected in far fewer placenta samples than in thrice-weekly urine and meconium samples, a result suggesting a short detection window for placenta.
conclusionsQuantitative methadone and EDDP measurement may predict NAS severity. The placenta reflects in utero drug exposure for a shorter time than meconium but may be useful when meconium is unavailable or if documentation of recent exposure is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.